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TitleMetabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis.
Journal, issue, pagesScience, Vol. 388, Issue 6746, Page eado4188, Year 2025
Publish dateMay 1, 2025
AuthorsHui Lin / Chuanshun Ma / Kui Cai / Lulu Guo / Xuemei Wang / Lin Lv / Chao Zhang / Jun Lin / Daolai Zhang / Chuan Ye / Tengwei Wang / Shenming Huang / Jifei Han / Zihao Zhang / Junyan Gao / Mingxiang Zhang / Zhao Pu / Fengyang Li / Yongyuan Guo / Xiaojun Zhou / Chengxue Qin / Fan Yi / Xiao Yu / Wei Kong / Changtao Jiang / Jin-Peng Sun /
PubMed AbstractCeramides play a central role in human health and disease, yet their role as systemic signaling molecules remain poorly understood. In this work, we identify formyl peptide receptor 2 (FPR2) as a ...Ceramides play a central role in human health and disease, yet their role as systemic signaling molecules remain poorly understood. In this work, we identify formyl peptide receptor 2 (FPR2) as a membrane receptor that specifically binds long-chain ceramides (C14 to C20). In brown and beige adipocytes, C16:0 ceramide binding to FPR2 inhibits thermogenesis through G cyclic adenosine monophosphate signaling pathways, an effect that is reversed in the absence of FPR2. We present three cryo-electron microscopy structures of FPR2 in complex with G trimers bound to C16:0, C18:0, and C20:0 ceramides. The hydrophobic tails are deeply embedded in the orthosteric ligand pocket, which has a limited amount of plasticity. Modification of the ceramide binding motif in closely related receptors, such as FPR1 or FPR3, converts them from inactive to active ceramide receptors. Our findings provide a structural basis for adipocyte thermogenesis mediated by FPR2.
External linksScience / PubMed:40080544
MethodsEM (single particle)
Resolution3.2 Å
Structure data

38964

8y62

EMDB-38964, PDB-8y62:
Cryo-EM structure of the C16:0 ceramide-bound FPR2-Gi complex
Method: EM (single particle) / Resolution: 3.2 Å

38965

8y63

EMDB-38965, PDB-8y63:
Cryo-EM structure of the C20:0 ceramide-bound FPR2-Gi complex
Method: EM (single particle) / Resolution: 3.2 Å

61484

9jhj

EMDB-61484, PDB-9jhj:
Cryo-EM structure of the C18:0 ceramide-bound FPR2-Gi complex
Method: EM (single particle) / Resolution: 3.2 Å

Chemicals

ChemComp-16C:
N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE

PDB-1lxr:
Unknown entry

ChemComp-18C:
N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)STEARAMIDE

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsMEMBRANE PROTEIN / Ceramide / GPCR

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