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TitleA Novel Antibody Against the Non-Receptor-Binding Domain Region of Middle East Respiratory Syndrome Coronavirus Spike Protein.
Journal, issue, pagesJ Infect Dis, Vol. 232, Issue 4, Page 982-992, Year 2025
Publish dateOct 15, 2025
AuthorsSo-Young Lee / Hye-Min Woo / Hyunbum Jeon / Nayoung Kim / Da Sol Kim / Chan Ki Park / Hyun-Joo Kim / Kyung-Chang Kim / Joo-Yeon Lee / Kunwoong Park / Youngki Yoo / Kiju Choi / Hansaem Lee /
PubMed AbstractThe Middle East respiratory syndrome coronavirus (MERS-CoV) was first identified in 2012 and has since spread worldwide. To date, no vaccines or therapeutics against MERS-CoV have been approved for ...The Middle East respiratory syndrome coronavirus (MERS-CoV) was first identified in 2012 and has since spread worldwide. To date, no vaccines or therapeutics against MERS-CoV have been approved for clinical use. The spike protein of MERS-CoV facilitates attachment and fusion with target cell membranes. Therefore, inhibiting S protein attachment represents a key therapeutic strategy for treating early MERS-CoV infection. Herein, we present 7 human neutralizing antibodies (KNIH-58, -68, -72, -78, -88, -90, and -95) against MERS-CoV. KNIH-58 and -68 bound to the receptor-binding subdomain (RBD) of the spike protein, while the other 5 monoclonal antibodies did not. KNIH-88, which targets the non-RBD region, exhibited potent neutralizing activities in vitro and in a transgenic mouse model, with similar results for KNIH-58. Structural analysis of KNIH-88 bound to the spike protein revealed novel epitopes in the non-RBD region. These findings may facilitate therapeutic and prophylactic antibody development against MERS-CoV.
External linksJ Infect Dis / PubMed:40241666
MethodsEM (single particle)
Resolution3.11 Å
Structure data

60978

9ixv

EMDB-60978, PDB-9ixv:
Cryo-EM structure of MERS-CoV S1-NTD bound with KNIH-88 Fab
Method: EM (single particle) / Resolution: 3.11 Å

Source
  • homo sapiens (human)
  • middle east respiratory syndrome-related coronavirus
KeywordsVIRAL PROTEIN / monoclonal antibody / MERS-CoV S1-NTD / KNIH-88 / VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX

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