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Structure paper

TitleStructural insights into the agonist activity of the nonpeptide modulator JR14a on C3aR.
Journal, issue, pagesCell Discov, Vol. 11, Issue 1, Page 7, Year 2025
Publish dateJan 10, 2025
AuthorsPing Luo / Wenwen Xin / Shimeng Guo / Xin Li / Qing Zhang / Youwei Xu / Xinheng He / Yue Wang / Wenjia Fan / Qingning Yuan / Kai Wu / Wen Hu / Youwen Zhuang / H Eric Xu / Xin Xie /
External linksCell Discov / PubMed:39788969 / PubMed Central
MethodsEM (single particle)
Resolution2.87 - 3.0 Å
Structure data

60525

8zwf

EMDB-60525, PDB-8zwf:
cryoEM structure of JR14a bound C3aR-BRIL-BAG2 complex
Method: EM (single particle) / Resolution: 3.0 Å

60526

8zwg

EMDB-60526, PDB-8zwg:
cryoEM structure of JR14a bound C3aR-Gi complex
Method: EM (single particle) / Resolution: 2.87 Å

Chemicals

PDB-1d9a:
SOLUTION STRUCTURE OF THE SECOND RNA-BINDING DOMAIN (RBD2) OF HU ANTIGEN C (HUC)

Source
  • homo sapiens (human)
  • rattus norvegicus (Norway rat)
  • synthetic construct (others)
  • bos taurus (domestic cattle)
  • escherichia coli (E. coli)
KeywordsIMMUNE SYSTEM / complement receptor / C3aR / Non-peptide agonist / JR14a

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