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TitleVisualisation of stepwise de-repression of TFIIH in global-genome nucleotide excision repair
Journal, issue, pagesTo Be Published
Publish dateFeb 3, 2026 (structure data deposition date)
Authorsde Martin Garrido N / Haste CAF / Feng J / Cronin NB / Greber BJ
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.29 - 4.6 Å
Structure data

56544

28jm

EMDB-56544, PDB-28jm:
Cryo-EM structure of the human holo-TFIIH and XPC initial encounter complex
Method: EM (single particle) / Resolution: 3.29 Å

56551

28js

EMDB-56551, PDB-28js:
Cryo-EM structure of the human holo-TFIIH-XPC complex bound to bulky lesion-mimic DNA (composite map)
Method: EM (single particle) / Resolution: 3.32 Å

EMDB-56553: Multi-body refinement component 1 of the cryo-EM structure of the human holo-TFIIH-XPC complex bound to bulky lesion-mimic DNA
Method: EM (single particle) / Resolution: 3.5 Å

56566

28jv

EMDB-56566, PDB-28jv:
Cryo-EM structure of the human holo-TFIIH-XPC complex bound to bulky lesion-mimic DNA (consensus map)
Method: EM (single particle) / Resolution: 3.91 Å

EMDB-56568: Multi-body refinement component 2 of the cryo-EM structure of the human holo-TFIIH-XPC complex bound to bulky lesion-mimic DNA
Method: EM (single particle) / Resolution: 3.7 Å

EMDB-56572: Multi-body refinement component 3 of the cryo-EM structure of the human holo-TFIIH-XPC complex bound to bulky lesion-mimic DNA
Method: EM (single particle) / Resolution: 4.6 Å

56573

28ke

EMDB-56573, PDB-28ke:
Cryo-EM structure of the human holo-TFIIH-XPC-XPA complex bound to bulky lesion-mimic DNA
Method: EM (single particle) / Resolution: 3.6 Å

Chemicals

ChemComp-SF4:
IRON/SULFUR CLUSTER

ChemComp-ZN:
Unknown entry

ChemComp-CA:
Unknown entry

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsDNA BINDING PROTEIN / Nucleotide excision repair / DNA Repair / helicase / transcription factor

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