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TitleElucidating the relationship between affinity and potency in the performance of IgE as therapeutic antibodies for cancers with low antigen densities
Journal, issue, pagesTo Be Published
Publish dateOct 29, 2025 (structure data deposition date)
AuthorsBirtley J / Johnson RM / Regan L / Soni K / Pye VE / Fitzgerald K
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.0 - 3.5 Å
Structure data

55517

9t3r

EMDB-55517, PDB-9t3r:
Structure of human HER2 in complex with EPS232 Fab
Method: EM (single particle) / Resolution: 3.5 Å

55518

9t3s

EMDB-55518, PDB-9t3s:
Structure of human HER2 in complex with EPS226 Fab
Method: EM (single particle) / Resolution: 3.0 Å

Source
  • homo sapiens (human)
KeywordsANTITUMOR PROTEIN / Antibody Fab / Complex / cancer / extracellular domain.

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