+検索条件
-Structure paper
| タイトル | Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape. |
|---|---|
| ジャーナル・号・ページ | Science, Vol. 392, Issue 6795, Page eaea6343, Year 2026 |
| 掲載日 | 2026年4月16日 |
著者 | Benjamin L Springstein / Manjunath G Javoor / Daniela Megrian / Roman Hajdu / Dustin M Hanke / Bettina Zens / Gregor L Weiss / Florian K M Schur / Martin Loose / ![]() |
| PubMed 要旨 | Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular organization. The plasmid-encoded ParMRC system forms actin-like filaments that segregate low-copy number plasmids. In ...Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular organization. The plasmid-encoded ParMRC system forms actin-like filaments that segregate low-copy number plasmids. In multicellular cyanobacteria such as sp., we found that a chromosomally encoded ParMR system has evolved into a cytoskeletal system named CorMR with a function in cell shape control rather than DNA segregation. Live-cell imaging, in vitro reconstitution, and cryo-electron microscopy revealed that CorM formed dynamically unstable, antiparallel double-stranded filaments that were recruited to the membrane by CorR through an amphipathic helix conserved in multicellular cyanobacteria. CorMR filaments were regulated by MinC, which excluded them from the poles and division plane. Comparative genomics indicated that the repurposing of ParMR and Min systems coevolved with cyanobacterial multicellularity, highlighting the evolutionary plasticity of cytoskeletal systems in bacteria. |
リンク | Science / PubMed:41990175 |
| 手法 | EM (単粒子) / EM (トモグラフィー) |
| 解像度 | 3.92 - 7.14 Å |
| 構造データ | EMDB-54060, PDB-9rmi: ![]() EMDB-54061: Cryo-EM structure of the CorM filament from cyanobacterium Anabaena sp. PCC 7120 ![]() EMDB-54062: Cryo-EM structure of the delta1-40 CorM filament from cyanobacterium Anabaena sp. PCC 7120 ![]() EMDB-55454: Cryo-electron tomogram of cyanobacterium Anabaena sp. PCC 7120 with putative CorM filaments (Isonet-processed) ![]() EMDB-55455: Cryo-electron tomogram of delta-cse mutant cyanobacterium Anabaena sp. PCC 7120 with putative CorM filaments |
| 化合物 | ![]() ChemComp-ADP: |
| 由来 |
|
キーワード | STRUCTURAL PROTEIN / Cell shape / cytoskeleton |
ムービー
コントローラー
構造ビューア
万見文献について



著者

リンク






nostoc sp. pcc 7120 = fachb-418 (バクテリア)
キーワード