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TitleDual E3 ligase recruitment by monovalent degraders enables redundant and tunable degradation of SMARCA2/4.
Journal, issue, pagesTo Be Published
Publish dateJul 25, 2025 (structure data deposition date)
AuthorsSpiteri VA / Segal D / Correa-Saez A / Iso K / Casement R / Munoz i Ordono M / Nakasone MA / Sathe G / Schatz C / Peters H ...Spiteri VA / Segal D / Correa-Saez A / Iso K / Casement R / Munoz i Ordono M / Nakasone MA / Sathe G / Schatz C / Peters H / Doward M / Kainacher L / Cowan AD / Ciulli A / Winter GE
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.3 Å
Structure data

54549

9s3r

EMDB-54549, PDB-9s3r:
Ternary complex structure of compound 1 bound to SMARCA2 bromodomain and DCAF16:DDB1deltaBPB
Method: EM (single particle) / Resolution: 3.3 Å

Chemicals

ChemComp-ZN:
Unknown entry

PDB-1jlv:
Anopheles dirus species B glutathione S-transferases 1-3

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / Protein complex / covalent degrader / targeted protein degradation / E3 ligase

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