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TitleIdentification of a novel fiber shaft structural motif and overexpression of key transcripts elucidated in human adenovirus D 10.
Journal, issue, pagesPLoS Pathog, Vol. 22, Issue 4, Page e1014182, Year 2026
Publish dateApr 28, 2026
AuthorsRosie M Mundy / Kasim Waraich / Emily A Bates / Pierre J Rizkallah / Alexander T Baker / Mark T Young / Edward Morris / Paula C A da Fonseca / Carly M Bliss / David Matthews / David Bhella / Alan L Parker /
PubMed AbstractAdenoviruses are widely used as vectors for subunit vaccines and oncolytic therapies. Efficient vectors must infect target cells and deliver therapeutic transgenes at high levels. Species D ...Adenoviruses are widely used as vectors for subunit vaccines and oncolytic therapies. Efficient vectors must infect target cells and deliver therapeutic transgenes at high levels. Species D adenoviruses, such as human adenovirus type 10 (HAdV-D10), are promising candidates due to low seroprevalence in humans. Here, we present the cryo-electron microscopy structure of the HAdV-D10 capsid alongside transcriptomic profiling of infected cells to inform vector development. The fiber shaft, essential for cell entry, was resolved at 10 Å, revealing a previously uncharacterized 'umbrella' motif. Viral transcript analysis using an ORF-centric pipeline uncovered key differences from HAdV-C5, including abundant expression of a transcript encoding a protein equivalent to mature protein VII. These findings highlight the importance of detailed vector characterization prior to clinical translation and support the advancement of HAdV-D10 as a next-generation platform for gene delivery and vaccine development.
External linksPLoS Pathog / PubMed:42048387 / PubMed Central
MethodsEM (single particle)
Resolution3.3 - 4.61 Å
Structure data

EMDB-53655: Human Adenovirus D 10 Fiber Shaft by Focussed Refinement
Method: EM (single particle) / Resolution: 4.61 Å

53736

9r78

EMDB-53736, PDB-9r78:
Human Adenovirus D 10 Capsid Structure
Method: EM (single particle) / Resolution: 3.3 Å

Source
  • human adenovirus d10
KeywordsVIRUS / adenovirus / capsid / conjunctivitis

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