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TitleA cereblon (CRBN) molecular glue degrader of NIMA-related kinase 7 (NEK7) reveals a context-dependent role in NLRP3 inflammasome activation
Journal, issue, pagesBiorxiv, Year 2024
Publish dateOct 22, 2024 (structure data deposition date)
AuthorsSylvain A / Stoehr N / Ma F / Cernijenko A / Schroder M / Khoshouei M / Vogelsanger M / Schoenboerner M / Burke A / Pasupuleti R ...Sylvain A / Stoehr N / Ma F / Cernijenko A / Schroder M / Khoshouei M / Vogelsanger M / Schoenboerner M / Burke A / Pasupuleti R / Solomon J / Paulk J / Xu L / Dawson J / Begue D / Lefeuvre P / Ahrne E / Hofmann A / Dickson CJ / Arabin P / Zimmerlin A / Kiffe M / Froehlicher M / Boersig T / Elhajouji A / Brichet M / Menon S / Liu S / Mueller M / Wartchow C / Lin J / Cardona Gloria Y / Dickhofer S / Weber ANR / Welzel T / Kuemmerle-Deschner J / Farady CJ / Pulz R / Bornancin F / Buckley DL / Bassi ZI
External linksBiorxiv / Search PubMed
MethodsEM (single particle)
Resolution3.4 Å
Structure data

51881

9h59

EMDB-51881, PDB-9h59:
Cryo-EM structure of DDB1-CRBN in complex with NK7-902 and NEK7
Method: EM (single particle) / Resolution: 3.4 Å

Chemicals

PDB-1isp:
Crystal structure of Bacillus subtilis lipase at 1.3A resolution

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / CRBN / DDB1 / NEK7

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