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Structure paper

TitleThe structure of human scavenger receptor CD163 in complex with haptoglobin-hemoglobin discloses the molecular mechanism for hemoglobin scavenging.
Journal, issue, pagesTo Be Published
Publish dateMay 27, 2024 (structure data deposition date)
AuthorsEtzerodt E / Mikkelsen JH / Torvund-Jensen M / Hennig D / Boesen T / Graversen JH / Moestrup SK / Kollman JM / Andersen CBF
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.87 - 4.46 Å
Structure data

50444

9fhb

EMDB-50444, PDB-9fhb:
Cryo-EM structure of human CD163 SRCR2-4 in complex with haptoglobin-hemoglobin
Method: EM (single particle) / Resolution: 3.87 Å

50570

9fmu

EMDB-50570, PDB-9fmu:
Cryo-EM structure of human CD163 SRCR1-9 in complex with haptoglobin-hemoglobin
Method: EM (single particle) / Resolution: 4.46 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-CA:
Unknown entry

Source
  • homo sapiens (human)
KeywordsENDOCYTOSIS / Scavenging receptor / oxygen transport / complex / hemolysis / inflammation

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