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TitleGenetic activation of Volume-Regulated Anion Channels cause a multisystem disorder
Journal, issue, pagesTo Be Published
Publish dateApr 11, 2024 (structure data deposition date)
AuthorsRutz S / Quinodoz M / Peter V / Garavelli L / Innes MA / Kellenberger S / Peng Z / Barone A / Campos-Xavier B / Unger S ...Rutz S / Quinodoz M / Peter V / Garavelli L / Innes MA / Kellenberger S / Peng Z / Barone A / Campos-Xavier B / Unger S / Rivolta C / Dutzler R / Superti-Furga A
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.41 - 7.32 Å
Structure data

50072

9ezc

EMDB-50072, PDB-9ezc:
Structure of the extracellular subdomain of a homomeric LRRC8C truncation disease mutant
Method: EM (single particle) / Resolution: 3.41 Å

EMDB-50073: Cryo-EM structure of a homomeric LRRC8C truncation disease mutant, with C1 symmetry
Method: EM (single particle) / Resolution: 7.32 Å

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / Anion channel / Volume regulation / disease mutation

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