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TitleSubstrate Mimicry by Inhibitors of the Mycobacterium tuberculosis 20S Proteasome and Their Activity against Mycobacteria In Vitro and in Macrophages
Journal, issue, pagesAcs Chem. Biol., Year 2026
Publish dateMar 12, 2025 (structure data deposition date)
AuthorsGu X / Rowheder PJ / Yu Z / Mohapatra A / Lun S / Jiang X / Li D / Yan NL / Detomasi TC / Pomares DFT ...Gu X / Rowheder PJ / Yu Z / Mohapatra A / Lun S / Jiang X / Li D / Yan NL / Detomasi TC / Pomares DFT / Chen Y / Gestwicki JE / Lin G / Bishai WR / Ernst JD / Cheng Y / Craik CS / Sello JK
External linksAcs Chem. Biol. / Search PubMed
MethodsEM (single particle)
Resolution2.16 Å
Structure data

49668

9nql

EMDB-49668, PDB-9nql:
Cryo electron microscopic analysis of the adduct of syringolin analog with the Mtb 20S proteasome
Method: EM (single particle) / Resolution: 2.16 Å

Chemicals

PDB-1b0m:
ACONITASE R644Q:FLUOROCITRATE COMPLEX

Source
  • mycobacterium tuberculosis (bacteria)
KeywordsHYDROLASE/ANTIBIOTIC / Proteasome Inhibitor / Mycobacterium tuberculosis / HYDROLASE-ANTIBIOTIC complex

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