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TitleStructure of the Thin Filament in Human iPSC-derived Cardiomyocytes and its Response to Heart Disease
Journal, issue, pagesTo Be Published
Publish dateFeb 21, 2025 (structure data deposition date)
AuthorsWoldeyes RA / Chiu W
External linksSearch PubMed
MethodsEM (subtomogram averaging)
Resolution8.7 - 19.5 Å
Structure data

EMDB-49344: In situ structure of the cardiac thin filament without troponin from isogenic control human induced pluripotent stem cell-derived cardiomyocytes (AICS-0097-113 ACTN2-mEGFP MYH7(WT/WT))
Method: EM (subtomogram averaging) / Resolution: 8.7 Å

EMDB-49345: In situ structure of the cardiac thin filament without troponin from untreated human induced pluripotent stem cell-derived cardiomyocytes (SCVI-273)
Method: EM (subtomogram averaging) / Resolution: 9.1 Å

EMDB-49346: In situ structure of the cardiac thin filament without troponin from MYH7(WT/G256E) human induced pluripotent stem cell-derived cardiomyocytes (AICS-0097-141 ACTN2-mEGFP MYH7(WT/G256E))
Method: EM (subtomogram averaging) / Resolution: 9.3 Å

EMDB-49348: In situ structure of the cardiac thin filament without troponin from doxorubicin-treated human induced pluripotent stem cell-derived cardiomyocytes (SCVI-273)
Method: EM (subtomogram averaging) / Resolution: 9.5 Å

EMDB-49349: In situ structure of the cardiac thin filament with troponin from isogenic control human induced pluripotent stem cell-derived cardiomyocytes (AICS-0097-113 ACTN2-mEGFP MYH7(WT/WT))
Method: EM (subtomogram averaging) / Resolution: 19.5 Å

EMDB-49350: In situ structure of the cardiac thin filament with troponin from untreated human induced pluripotent stem cell-derived cardiomyocytes (SCVI-273)
Method: EM (subtomogram averaging) / Resolution: 18.0 Å

EMDB-49351: In situ structure of the cardiac thin filament with troponin from MYH7(WT/G256E) human induced pluripotent stem cell-derived cardiomyocytes (AICS-0097-141 ACTN2-mEGFP MYH7(WT/G256E))
Method: EM (subtomogram averaging) / Resolution: 12.4 Å

EMDB-49352: ln situ structure of the cardiac thin filament with troponin from doxorubicin-treated human induced pluripotent stem cell-derived cardiomyocytes (SCVI-273)
Method: EM (subtomogram averaging) / Resolution: 12.4 Å

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  • Homo sapiens (human)

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