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Structure paper

TitleMechanistic insights into RNA chaperoning by Ro60 and La autoantigens
Journal, issue, pagesCell(Cambridge,Mass. ), Year 2026
Publish dateFeb 20, 2025 (structure data deposition date)
AuthorsNam H / Deme JC / Sim S / Boccitto M / Lea SM / Wolin SL
External linksCell(Cambridge,Mass. ) / Search PubMed
MethodsEM (single particle)
Resolution2.7 - 3.5 Å
Structure data

EMDB-49327: Cryo-EM structure of Ro60/U-tailed 5S rRNA complex
Method: EM (single particle) / Resolution: 3.5 Å

49328

9nen

EMDB-49328, PDB-9nen:
Cryo-EM structure of human Ro60
Method: EM (single particle) / Resolution: 3.5 Å

49329

9nep

EMDB-49329, PDB-9nep:
Cryo-EM structure of Ro60/minimal misfolded pre-5S rRNA complex
Method: EM (single particle) / Resolution: 2.7 Å

EMDB-49353: Cryo-EM structure of Ro60/La/truncated misfolded human pre-5S rRNA complex with Fab, consensus map
Method: EM (single particle) / Resolution: 3.1 Å

EMDB-49354: Cryo-EM structure of Ro60/La/truncated misfolded human pre-5S rRNA complex with Fab, focused map
Method: EM (single particle) / Resolution: 3.3 Å

49355

9nf8

EMDB-49355, PDB-9nf8:
Cryo-EM structure of Ro60/La/truncated misfolded human pre-5S rRNA complex with Fab, composite map
Method: EM (single particle) / Resolution: 3.1 Å

EMDB-49357: Cryo-EM structure of Ro60/La/minimal misfolded pre-5S rRNA complex with Fab, consensus map
Method: EM (single particle) / Resolution: 2.7 Å

EMDB-49358: Cryo-EM structure of Ro60/La/minimal misfolded pre-5S rRNA complex with Fab, N-term La/Fab focused map
Method: EM (single particle) / Resolution: 2.8 Å

EMDB-49359: Cryo-EM structure of Ro60/La/minimal misfolded pre-5S rRNA complex with Fab, C-term La focused map
Method: EM (single particle) / Resolution: 3.0 Å

49360

9nfa

EMDB-49360, PDB-9nfa:
Cryo-EM structure of Ro60/La/minimal misfolded pre-5S rRNA complex with Fab, composite map
Method: EM (single particle) / Resolution: 2.7 Å

Chemicals

ChemComp-MG:
Unknown entry

Source
  • homo sapiens (human)
  • xenopus laevis (African clawed frog)
KeywordsRNA BINDING PROTEIN/RNA / Ro60 autoantigen / RNA chaperone / RNA folding / RNA BINDING PROTEIN / RNA BINDING PROTEIN-RNA complex / La autoantigen

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