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Structure paper

TitleConformational plasticity of human acid-sensing ion channel 1a
Journal, issue, pagesTo Be Published
Publish dateOct 24, 2024 (structure data deposition date)
AuthorsCahill J / Hartfield KA / Heusser SA / Ritter N / Poulsen MH / Yoshioka C / Pless SA / Baconguis I
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.33 - 3.41 Å
Structure data

47503

9e4a

EMDB-47503, PDB-9e4a:
Human ASIC1a at pH 8.5 with domain-swapped transmembrane domain
Method: EM (single particle) / Resolution: 2.74 Å

47504

9e4b

EMDB-47504, PDB-9e4b:
Human ASIC1a at pH 7.5 with domain-swapped transmembrane domain
Method: EM (single particle) / Resolution: 3.09 Å

47505

9e4c

EMDB-47505, PDB-9e4c:
Human ASIC1a at pH 7.5 with partial transmembrane domain
Method: EM (single particle) / Resolution: 3.41 Å

47506

9e4d

EMDB-47506, PDB-9e4d:
Human ASIC1a at pH 7.5 with linear transmembrane domain
Method: EM (single particle) / Resolution: 3.19 Å

47507

9e4e

EMDB-47507, PDB-9e4e:
Human ASIC1a at pH 6.5 with linear transmembrane domain
Method: EM (single particle) / Resolution: 3.16 Å

47508

9e4f

EMDB-47508, PDB-9e4f:
Human ASIC1a at pH 5.7 with domain-swapped transmembrane domain
Method: EM (single particle) / Resolution: 2.69 Å

47509

9e4g

EMDB-47509, PDB-9e4g:
Human ASIC1a at pH 5.7 with linear transmembrane domain
Method: EM (single particle) / Resolution: 2.8 Å

47510

9e4h

EMDB-47510, PDB-9e4h:
Human ASIC1a at pH 5.7 with rotated, domain-swapped transmembrane domain
Method: EM (single particle) / Resolution: 2.61 Å

47511

9e4i

EMDB-47511, PDB-9e4i:
Human ASIC1a at pH 7.5 in complex with MitTx
Method: EM (single particle) / Resolution: 2.33 Å

47512

9e4j

EMDB-47512, PDB-9e4j:
Human ASIC1a at pH 6.5 in complex with MitTx
Method: EM (single particle) / Resolution: 2.87 Å

47513

9e4k

EMDB-47513, PDB-9e4k:
Human ASIC1a at pH 8.5, T26V mutation
Method: EM (single particle) / Resolution: 2.77 Å

Source
  • homo sapiens (human)
  • micrurus tener tener (cobra)
KeywordsMEMBRANE PROTEIN / Ion channel / Trimer / Toxin

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