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Structure paper

TitleStructural mechanism of anti-MHC-I antibody blocking of inhibitory NK cell receptors in tumor immunity.
Journal, issue, pagesCommun Biol, Year 2026
Publish dateFeb 2, 2026
AuthorsJiansheng Jiang / Abir K Panda / Kannan Natarajan / Haotian Lei / Shikha Sharma / Lisa F Boyd / Reanne R Towler / Sruthi Chempati / Javeed Ahmad / Abraham J Morton / Zabrina C Lang / Yi Sun / Nikolaos Sgourakis / Martin Meier-Schellersheim / Rick K Huang / Ethan M Shevach / David H Margulies /
PubMed AbstractAnti-major histocompatibility complex class I (MHC-I) mAbs can stimulate immune responses to tumors and infections by blocking suppressive signals delivered via various immune inhibitory receptors. ...Anti-major histocompatibility complex class I (MHC-I) mAbs can stimulate immune responses to tumors and infections by blocking suppressive signals delivered via various immune inhibitory receptors. To understand such functions, we determined the structure of a highly cross-reactive anti-human MHC-I mAb, B1.23.2, in complex with the MHC-I molecule HLA-B*44:05 by both cryo-electron microscopy (cryo-EM) and X-ray crystallography. Structural models determined by the two methods were essentially identical revealing that B1.23.2 binds a conserved region on the α2 helix that overlaps the killer immunoglobulin-like receptor (KIR) binding site. Structural comparison to KIR/HLA complexes reveals a mechanism by which B1.23.2 blocks inhibitory receptor interactions, leading to natural killer (NK) cell activation. B1.23.2 treatment of the human KLM-1 pancreatic cancer model in humanized (NSG-IL15) mice provides evidence of suppression of tumor growth. Such anti-MHC-I mAb that block inhibitory KIR/HLA interactions may prove useful for tumor immunotherapy.
External linksCommun Biol / PubMed:41629525
MethodsEM (single particle) / X-ray diffraction
Resolution2.67 - 3.44 Å
Structure data

46600

9d72

EMDB-46600, PDB-9d72:
CryoEM structure of anti-MHC-I Fab M1/42 complex with H2-Dd
Method: EM (single particle) / Resolution: 2.67 Å

46601

9d73

EMDB-46601, PDB-9d73:
CryoEM structure of anti-MHC-I mAb B1.23.2 complex with HLA-B44:05
Method: EM (single particle) / Resolution: 3.02 Å

46602

9d74

EMDB-46602, PDB-9d74:
CryoEM structure of anti-MHC-I Fab B1.23.2 complex with HLA-B44:05
Method: EM (single particle) / Resolution: 3.31 Å

70276

9oa9

EMDB-70276, PDB-9oa9:
CryoEM structure of anti-MHC-I mAb B1.23.2 Fc domains
Method: EM (single particle) / Resolution: 3.44 Å

PDB-8tq6:
Crystal structure of Fab.B1.23.2 in complex with MHC-I (HLA-B*44:05)
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Source
  • rattus norvegicus (Norway rat)
  • mus musculus (house mouse)
  • synthetic construct (others)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / histocompatibility complex class I / MHC-I / immune response / immune system Fab / antibody / anti-MHC antibody / cancer tumor / ANTITUMOR PROTEIN/Immune System / anti-mouse-mAb / H2-Dd / M1/42 / anti-MHC-I antibody / anti-tumor / cancer immunotherapy / ANTITUMOR PROTEIN / ANTITUMOR PROTEIN-Immune System complex / anti-human-mAb / B1.23.2 / Fab / HLA

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