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TitleCryo-electron tomography reveals the microtubule-bound form of inactive LRRK2
Journal, issue, pagesElife, Year 2024
Publish dateJul 1, 2024 (structure data deposition date)
AuthorsChen S / Basiashvili T / Hutchings J / Sanz Murillo M / Villagran Suarez A / Alegrio Louro J / Leschziner AE / Villa E
External linksElife / Search PubMed
MethodsEM (subtomogram averaging)
Resolution5.9 - 8.9 Å
Structure data

EMDB-45592: 13-pf microtubule from the LRRK2(I2020T) and MLi-2 dataset
Method: EM (subtomogram averaging) / Resolution: 5.9 Å

EMDB-45593: Focused refinement map of WD40:ARM/ANK interface from LRRK2(I2020T) MLi-2 dataset
Method: EM (subtomogram averaging) / Resolution: 8.9 Å

EMDB-45594: Full-length autoinhibited LRRK2(I2020T) co-polymerized with microtubules and MLi-2
Method: EM (subtomogram averaging) / Resolution: 8.3 Å

EMDB-45595: Full-length autoinhibited LRRK2 on microtubules with MLi-2
Method: EM (subtomogram averaging) / Resolution: 8.3 Å

EMDB-45596: Full-length autoinhibited LRRK2 on microtubules with GZD-824
Method: EM (subtomogram averaging) / Resolution: 8.1 Å

Source
  • Mus musculus (house mouse)
  • Homo sapiens (human)

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