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TitleA broadly-neutralizing antibody against Orthoebolavirus glycoprotein that potentiates the breadth and neutralization of other antibodies.
Journal, issue, pagesNpj Viruses, Year 2026
Publish dateMay 7, 2026
AuthorsFrancesca R Donnellan / Vamseedhar Rayaprolu / Pramila Rijal / Victoria O'Dowd / Amar Parvate / Heather Callaway / Chitra Hariharan / Dipti Parekh / Sean Hui / Kelly C L Shaffer / Ruben Diaz Avalos / Kathryn M Hastie / Lisa Schimanski / Helena Müller-Kräuter / Thomas Strecker / Ariane Balaram / Peter Halfmann / Erica Ollmann Saphire / Daniel J Lightwood / Alain R Townsend / Simon J Draper /
PubMed AbstractEbolavirus disease (EVD) is caused by multiple species of orthoebolavirus. Monoclonal antibodies (mAbs) against the virus glycoprotein (GP) are the only class of therapeutic approved for treatment of ...Ebolavirus disease (EVD) is caused by multiple species of orthoebolavirus. Monoclonal antibodies (mAbs) against the virus glycoprotein (GP) are the only class of therapeutic approved for treatment of EVD caused by Orthoebolavirus zairense (Ebola virus, EBOV). Therefore, mAbs targeting multiple orthoebolavirus species may represent the next generation of EVD therapeutics. Broadly reactive anti-GP mAbs were produced; among these, mAbs 11886 and 11883 were broadly neutralizing in vitro. A 3.0 Å cryo-electron microscopy structure of EBOV GP bound to both mAbs shows that 11886 binds a novel epitope bridging the glycan cap (GC), 3 pocket and GP2 N-terminus, whereas 11883 binds the receptor binding region (RBR) and GC. In vitro, 11886 synergized with a range of mAbs with epitope specificities spanning the RBR/GC, including 11883. Notably, 11886 increased the breadth of neutralization by partner mAbs against different orthoebolavirus species. These data provide a strategic route to design improved mAb-based next-generation EVD therapeutics.
External linksNpj Viruses / PubMed:42098405
MethodsEM (single particle)
Resolution3.0 Å
Structure data

44747

9bop

EMDB-44747, PDB-9bop:
A broadly-neutralizing antibody against Ebolavirus glycoprotein that can potentiate the breadth and neutralization potency of other anti-glycoprotein antibodies
Method: EM (single particle) / Resolution: 3.0 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • Ebola virus
  • oryctolagus cuniculus (rabbit)
  • ebolavirus
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / Ebola / IgG / neutralization / complex / glycoprotein / VIRAL PROTEIN-IMMUNE SYSTEM complex / ebolavirus

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