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TitleHuman Memory B Cells Harbor Diverse Cross-Neutralizing Antibodies against BK and JC Polyomaviruses.
Journal, issue, pagesImmunity, Vol. 50, Issue 3, Page 668-676.e5, Year 2019
Publish dateMar 19, 2019
AuthorsJohn M Lindner / Vanessa Cornacchione / Atul Sathe / Celine Be / Honnappa Srinivas / Elodie Riquet / Xavier-Charles Leber / Andreas Hein / Matthias B Wrobel / Meike Scharenberg / Thomas Pietzonka / Christian Wiesmann / Johanna Abend / Elisabetta Traggiai /
PubMed AbstractHuman polyomaviruses cause a common childhood infection worldwide and typically elicit a neutralizing antibody and cellular immune response, while establishing a dormant infection in the kidney with ...Human polyomaviruses cause a common childhood infection worldwide and typically elicit a neutralizing antibody and cellular immune response, while establishing a dormant infection in the kidney with minimal clinical manifestations. However, viral reactivation can cause severe pathology in immunocompromised individuals. We developed a high-throughput, functional antibody screen to examine the humoral response to BK polyomavirus. This approach enabled the isolation of antibodies from all peripheral B cell subsets and revealed the anti-BK virus antibody repertoire as clonally complex with respect to immunoglobulin sequences and isotypes (both IgM and IgG), including a high frequency of monoclonal antibodies that broadly neutralize BK virus subtypes and the related JC polyomavirus. Cryo-electron microscopy of a broadly neutralizing IgG single-chain variable fragment complexed with BK virus-like particles revealed the quaternary nature of a conserved viral epitope at the junction between capsid pentamers. These features unravel a potent modality for inhibiting polyomavirus infection in kidney transplant recipients and other immunocompromised patients.
External linksImmunity / PubMed:30824324
MethodsEM (single particle)
Resolution4.24 Å
Structure data

4398

6gg0

EMDB-4398, PDB-6gg0:
Cryo-EM structure of BK polyomavirus like particle in complex with single chain antibody ScFv41F17
Method: EM (single particle) / Resolution: 4.24 Å

Source
  • bk polyomavirus
  • homo sapiens (human)
KeywordsVIRUS LIKE PARTICLE / BK polyoma virus / Single chain antibody / cross neutralizing antibody

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