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TitleAtomic structures of naphthalene dipeptide micelles unravel mechanisms of assembly and gelation.
Journal, issue, pagesCell Rep Phys Sci, Vol. 5, Issue 2, Year 2024
Publish dateFeb 21, 2024
AuthorsRavi R Sonani / Simona Bianco / Bart Dietrich / James Doutch / Emily R Draper / Dave J Adams / Edward H Egelman /
PubMed AbstractPeptide-based biopolymers have gained increasing attention due to their versatile applications. A naphthalene dipeptide (2NapFF) can form chirality-dependent tubular micelles, leading to ...Peptide-based biopolymers have gained increasing attention due to their versatile applications. A naphthalene dipeptide (2NapFF) can form chirality-dependent tubular micelles, leading to supramolecular gels. The precise molecular arrangement within these micelles and the mechanism governing gelation have remained enigmatic. We determined, at near-atomic resolution, cryoelectron microscopy structures of the 2NapFF micelles LL-tube and LD-tube, generated by the stereoisomers (l,l)-2NapFF and (l,d)-2NapFF, respectively. The structures reveal that the fundamental packing of dipeptides is driven by the systematic π-π stacking of aromatic rings and that same-charge repulsion between the carbonyl groups is responsible for the stiffness of both tubes. The structural analysis elucidates how a single residue's altered chirality gives rise to markedly distinct tubular structures and sheds light on the mechanisms underlying the pH-dependent gelation of LL- and LD-tubes. The understanding of dipeptide packing and gelation mechanisms provides insights for the rational design of 2NapFF derivatives, enabling the modulation of micellar dimensions.
External linksCell Rep Phys Sci / PubMed:38464674 / PubMed Central
MethodsEM (helical sym.)
Resolution3.3 Å
Structure data

EMDB-42434: Cryo-EM of (L, L)-2NapFF micelle
Method: EM (helical sym.) / Resolution: 3.3 Å

EMDB-42436: Cryo-EM of (L,D)-2NapFF micelle
Method: EM (helical sym.) / Resolution: 3.3 Å

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