EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Physical basis of amyloid fibril polymorphism.
ジャーナル・号・ページ	Nat Commun, Vol. 9, Issue 1, Page 699, Year 2018
掲載日	2018年2月16日
著者	William Close / Matthias Neumann / Andreas Schmidt / Manuel Hora / Karthikeyan Annamalai / Matthias Schmidt / Bernd Reif / Volker Schmidt / Nikolaus Grigorieff / Marcus Fändrich /
PubMed 要旨	Polymorphism is a key feature of amyloid fibril structures but it remains challenging to explain these variations for a particular sample. Here, we report electron cryomicroscopy-based ...Polymorphism is a key feature of amyloid fibril structures but it remains challenging to explain these variations for a particular sample. Here, we report electron cryomicroscopy-based reconstructions from different fibril morphologies formed by a peptide fragment from an amyloidogenic immunoglobulin light chain. The observed fibril morphologies vary in the number and cross-sectional arrangement of a structurally conserved building block. A comparison with the theoretically possible constellations reveals the experimentally observed spectrum of fibril morphologies to be governed by opposing sets of forces that primarily arise from the β-sheet twist, as well as peptide-peptide interactions within the fibril cross-section. Our results provide a framework for rationalizing and predicting the structure and polymorphism of cross-β fibrils, and suggest that a small number of physical parameters control the observed fibril architectures.
リンク	Nat Commun / PubMed:29453354 / PubMed Central
手法	EM (らせん対称)
解像度	8.4 - 20.3 Å
構造データ	EMDB-3986: Morphology II - cross-beta amyloid fibril structure from the IGSNVVTWYQQL peptide of AL immunoglobulin light chain by cryo-EM 手法: EM (らせん対称) / 解像度: 8.4 Å EMDB-3987: Morphology III - cross-beta amyloid fibril structure from the IGSNVVTWYQQL peptide of AL immunoglobulin light chain by cryo-EM 手法: EM (らせん対称) / 解像度: 9.3 Å EMDB-3988: Morphology IV - cross-beta amyloid fibril structure from the IGSNVVTWYQQL peptide of AL immunoglobulin light chain by cryo-EM 手法: EM (らせん対称) / 解像度: 9.7 Å EMDB-3989: Morphology V - cross-beta amyloid fibril structure from the IGSNVVTWYQQL peptide of AL immunoglobulin light chain by cryo-EM 手法: EM (らせん対称) / 解像度: 9.4 Å EMDB-3990: Morphology VI - cross-beta amyloid fibril structure from the IGSNVVTWYQQL peptide of AL immunoglobulin light chain by cryo-EM 手法: EM (らせん対称) / 解像度: 13.4 Å EMDB-3991: Morphology VII - cross-beta amyloid fibril structure from the IGSNVVTWYQQL peptide of AL immunoglobulin light chain by cryo-EM 手法: EM (らせん対称) / 解像度: 15.9 Å EMDB-3992: Morphology VIII - cross-beta amyloid fibril structure from the IGSNVVTWYQQL peptide of AL immunoglobulin light chain by cryo-EM 手法: EM (らせん対称) / 解像度: 18.2 Å EMDB-3993: Morphology IX - cross-beta amyloid fibril structure from the IGSNVVTWYQQL peptide of AL immunoglobulin light chain by cryo-EM 手法: EM (らせん対称) / 解像度: 20.3 Å EMDB-3994: Morphology X - cross-beta amyloid fibril structure from the IGSNVVTWYQQL peptide of AL immunoglobulin light chain by cryo-EM 手法: EM (らせん対称) / 解像度: 17.7 Å
由来	Homo sapiens (ヒト)