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| Title | NMR analysis of a loop-bulge structure of UUCGA pentaloop. |
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| Journal, issue, pages | Biochem Biophys Res Commun, Vol. 691, Page 149327, Year 2024 |
| Publish date | Jan 8, 2024 |
 Authors | Rika Ichijo / Gota Kawai /  |
| PubMed Abstract | Although structures of many RNA loops, such as GNRA and UNCG tetraloops, were well known, it is still possible to find more RNA structures. In the present study, solution structure of an RNA fragment ...Although structures of many RNA loops, such as GNRA and UNCG tetraloops, were well known, it is still possible to find more RNA structures. In the present study, solution structure of an RNA fragment having UUCGA pentaloop was analyzed by NMR spectroscopy. It was found that the UUCG tetraloop is formed and the adenosine residue at the 3' side of the tetraloop is bulged out. The characteristic motif of the loop-bulge structure has also been found in other RNAs including CUUGU and CUGGC pentaloops. Along with the recently found T-hairpin structure with a UUUGAUU loop, in which UUUGA pentaloop and UU bulge are formed, the loop-bulge structures can be categorized as an RNA motif and it may be called as the integrated structure loop, I-loop. |
 External links | Biochem Biophys Res Commun / PubMed:38039839 |
| Methods | EM (single particle) / NMR (solution) |
| Resolution | 3.97 Å |
| Structure data | EMDB-39001, PDB-8y6u:  PDB-8k8b: |
| Source |
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 Keywords | RNA / penta loop / UUCG loop / TRANSCRIPTION/DNA / RNA polymerase / TRANSCRIPTION-DNA COMPLEX |
escherichia coli k-12 (bacteria)
mus musculus (house mouse)