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TitleTwo noncompeting human neutralizing antibodies targeting MPXV B6 show protective effects against orthopoxvirus infections.
Journal, issue, pagesNat Commun, Vol. 15, Issue 1, Page 4660, Year 2024
Publish dateMay 31, 2024
AuthorsRunchu Zhao / Lili Wu / Junqing Sun / Dezhi Liu / Pu Han / Yue Gao / Yi Zhang / Yanli Xu / Xiao Qu / Han Wang / Yan Chai / Zhihai Chen / George F Gao / Qihui Wang /
PubMed AbstractThe recent outbreak of mpox epidemic, caused by monkeypox virus (MPXV), poses a new threat to global public health. Here, we initially assessed the preexisting antibody level to the MPXV B6 protein ...The recent outbreak of mpox epidemic, caused by monkeypox virus (MPXV), poses a new threat to global public health. Here, we initially assessed the preexisting antibody level to the MPXV B6 protein in vaccinia vaccinees born before the end of the immunization program and then identified two monoclonal antibodies (MAbs), hMB621 and hMB668, targeting distinct epitopes on B6, from one vaccinee. Binding assays demonstrate that both MAbs exhibit broad binding abilities to B6 and its orthologs in vaccinia (VACV), variola (VARV) and cowpox viruses (CPXV). Neutralizing assays reveal that the two MAbs showed potent neutralization against VACV. Animal experiments using a BALB/c female mouse model indicate that the two MAbs showed effective protection against VACV via intraperitoneal injection. Additionally, we determined the complex structure of B6 and hMB668, revealing the structural feature of B6 and the epitope of hMB668. Collectively, our study provides two promising antibody candidates for the treatment of orthopoxvirus infections, including mpox.
External linksNat Commun / PubMed:38821921 / PubMed Central
MethodsEM (single particle)
Resolution3.46 Å
Structure data

38613

8xs3

EMDB-38613, PDB-8xs3:
Structure of MPXV B6 and D68 fab complex
Method: EM (single particle) / Resolution: 3.46 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
  • monkeypox virus
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / mpxv antibody / VIRAL PROTEIN-IMMUNE SYSTEM complex

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