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-Structure paper
Title | Molecular mechanism of substrate recognition and cleavage by human gamma-secretase |
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Journal, issue, pages | Science, Year 2024 |
Publish date | Nov 16, 2023 (structure data deposition date) |
Authors | Guo X / Li H / Yan C / Lei J / Zhou R / Shi Y |
External links | Search PubMed |
Methods | EM (single particle) |
Resolution | 2.9 - 4.5 Å |
Structure data | EMDB-38059, PDB-8x52: EMDB-38060, PDB-8x53: EMDB-38061, PDB-8x54: EMDB-39574: Cryo-EM structure of human gamma-secretase in complex with Abeta43 |
Chemicals | ChemComp-NAG: ChemComp-PC1: ChemComp-CLR: |
Source |
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Keywords | MEMBRANE PROTEIN / Intramembrane protease / gamma-secretase / presenilin-1 / MEMBRANE PROTEIN-HYDROLASE complex |