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TitleCryo-EM structures of African swine fever virus topoisomerase.
Journal, issue, pagesmBio, Vol. 14, Issue 5, Page e0122823, Year 2023
Publish dateAug 23, 2023
AuthorsYan Zhao / Wenhua Kuang / Qiyin An / Jinyue Li / Yong Wang / Zengqin Deng /
PubMed AbstractAfrican swine fever virus (ASFV) is a highly contagious virus that causes lethal hemorrhagic diseases known as African swine fever (ASF) with a case fatality rate of 100%. There is an urgent need to ...African swine fever virus (ASFV) is a highly contagious virus that causes lethal hemorrhagic diseases known as African swine fever (ASF) with a case fatality rate of 100%. There is an urgent need to develop anti-ASFV drugs. We determine the first high-resolution structures of viral topoisomerase ASFV P1192R in both the closed and open C-gate forms. P1192R shows a similar overall architecture with eukaryotic and prokaryotic type II topoisomerases, which have been successful targets of many antimicrobials and anticancer drugs, with the most similarity to yeast topo II. P1192R also exhibits differences in the details of active site configuration, which are important to enzyme activity. These two structures offer useful structural information for antiviral drug design and provide structural evidence to support that eukaryotic type IIA topoisomerase likely originated from horizontal gene transfer from the virus.
External linksmBio / PubMed:37610250 / PubMed Central
MethodsEM (single particle)
Resolution3.13 - 3.16 Å
Structure data

36119

8j9y

EMDB-36119: Cryo-EM structure of viral topoisomerase in conformation 1
PDB-8j9y: cryo-EM structure of viral topoisomerase in conformation 1
Method: EM (single particle) / Resolution: 3.16 Å

36120

8j9z

EMDB-36120: Cryo-EM structure of viral topoisomerase in conformation 2
PDB-8j9z: cryo-EM structure of viral topoisomerase in conformation 2
Method: EM (single particle) / Resolution: 3.13 Å

Source
  • african swine fever virus lis57
KeywordsVIRAL PROTEIN / topoisomerase

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