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TitleAn updated atlas of antibody evasion by SARS-CoV-2 Omicron sub-variants including BQ.1.1 and XBB.
Journal, issue, pagesCell Rep Med, Vol. 4, Issue 4, Page 100991, Year 2023
Publish dateApr 18, 2023
AuthorsQingwen He / Lili Wu / Zepeng Xu / Xiaoyun Wang / Yufeng Xie / Yan Chai / Anqi Zheng / Jianjie Zhou / Shitong Qiao / Min Huang / Guijun Shang / Xin Zhao / Youjun Feng / Jianxun Qi / George Fu Gao / Qihui Wang /
PubMed AbstractEmerging Omicron sub-variants are causing global concerns, and their immune evasion should be monitored continuously. We previously evaluated the escape of Omicron BA.1, BA.1.1, BA.2, and BA.3 from ...Emerging Omicron sub-variants are causing global concerns, and their immune evasion should be monitored continuously. We previously evaluated the escape of Omicron BA.1, BA.1.1, BA.2, and BA.3 from an atlas of 50 monoclonal antibodies (mAbs), covering seven epitope classes of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain (RBD). Here, we update the atlas of totally 77 mAbs against emerging sub-variants including BQ.1.1 and XBB and find that BA.4/5, BQ.1.1, and XBB display further evasion. Besides, investigation into the correlation of binding and neutralization of mAbs reveals the important role of antigenic conformation in mAb functioning. Moreover, the complex structures of BA.2 RBD/BD-604/S304 and BA.4/5 RBD/BD-604/S304/S309 further elucidate the molecular mechanism of antibody evasion by these sub-variants. By focusing on the identified broadly potent mAbs, we find a general hotspot epitope on the RBD, which could guide the design of vaccines and calls for new broad-spectrum countermeasures against COVID-19.
External linksCell Rep Med / PubMed:37019110 / PubMed Central
MethodsEM (single particle)
Resolution2.36 - 2.91 Å
Structure data

35063

8hws

EMDB-35063, PDB-8hws:
The complex structure of Omicron BA.4 RBD with BD604, S309, and S304
Method: EM (single particle) / Resolution: 2.36 Å

35064

8hwt

EMDB-35064, PDB-8hwt:
SARS-CoV-2 Omicron BA.2 RBD complexed with BD-604 and S304 Fab
Method: EM (single particle) / Resolution: 2.91 Å

Source
  • homo sapiens (human)
  • severe acute respiratory syndrome coronavirus 2
KeywordsIMMUNE SYSTEM/VIRAL PROTEIN / antibody viral protein complex / IMMUNE SYSTEM-VIRAL PROTEIN complex / RBD / antibody

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