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TitlePlasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M.
Journal, issue, pagesNat Commun, Vol. 14, Issue 1, Page 2650, Year 2023
Publish dateMay 8, 2023
AuthorsChenggong Ji / Hao Shen / Chen Su / Yaxin Li / Shihua Chen / Thomas H Sharp / Junyu Xiao /
PubMed AbstractPlasmodium falciparum causes the most severe malaria in humans. Immunoglobulin M (IgM) serves as the first line of humoral defense against infection and potently activates the complement pathway to ...Plasmodium falciparum causes the most severe malaria in humans. Immunoglobulin M (IgM) serves as the first line of humoral defense against infection and potently activates the complement pathway to facilitate P. falciparum clearance. A number of P. falciparum proteins bind IgM, leading to immune evasion and severe disease. However, the underlying molecular mechanisms remain unknown. Here, using high-resolution cryo-electron microscopy, we delineate how P. falciparum proteins VAR2CSA, TM284VAR1, DBLMSP, and DBLMSP2 target IgM. Each protein binds IgM in a different manner, and together they present a variety of Duffy-binding-like domain-IgM interaction modes. We further show that these proteins interfere directly with IgM-mediated complement activation in vitro, with VAR2CSA exhibiting the most potent inhibitory effect. These results underscore the importance of IgM for human adaptation of P. falciparum and provide critical insights into its immune evasion mechanism.
External linksNat Commun / PubMed:37156765 / PubMed Central
MethodsEM (single particle)
Resolution3.18 - 3.71 Å
Structure data

33538

7y09

EMDB-33538, PDB-7y09:
Cryo-EM structure of human IgM-Fc in complex with the J chain and the DBL domain of DBLMSP
Method: EM (single particle) / Resolution: 3.71 Å

EMDB-33539: Cryo-EM local structure of human IgM-Fc in complex with the J chain and the DBL domain of DBLMSP
Method: EM (single particle) / Resolution: 3.64 Å

33542

7y0h

EMDB-33542, PDB-7y0h:
Cryo-EM structure of human IgM-Fc in complex with the J chain and the P. falciparum VAR2CSA FCR3
Method: EM (single particle) / Resolution: 3.56 Å

33547

7y0j

EMDB-33547, PDB-7y0j:
Cryo-EM structure of human IgM-Fc in complex with the J chain and the P. falciparum TM284VAR1
Method: EM (single particle) / Resolution: 3.62 Å

33805

7yg2

EMDB-33805, PDB-7yg2:
Cryo-EM structure of human IgM-Fc in complex with the J chain and the DBL domain of DBLMSP2
Method: EM (single particle) / Resolution: 3.32 Å

EMDB-33806: Cryo-EM structure of human IgM-Fc in complex with the J chain and the DBL domain of DBLMSP2
Method: EM (single particle) / Resolution: 3.18 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • plasmodium falciparum (malaria parasite P. falciparum)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / malaria / immunoglobin / Complex / antibody

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