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-Structure paper
タイトル | Structural and functional analysis of an inter-Spike bivalent neutralizing antibody against SARS-CoV-2 variants. |
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ジャーナル・号・ページ | iScience, Vol. 25, Issue 6, Page 104431, Year 2022 |
掲載日 | 2022年6月17日 |
著者 | Yaning Li / Qing Fan / Bing Zhou / Yaping Shen / Yuanyuan Zhang / Lin Cheng / Furong Qi / Shuo Song / Yingying Guo / Renhong Yan / Bin Ju / Zheng Zhang / |
PubMed 要旨 | The different variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have attracted most public concern because they caused "wave and wave" COVID-19 pandemic. The initial step of ...The different variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have attracted most public concern because they caused "wave and wave" COVID-19 pandemic. The initial step of viral infection is mediated by the SARS-CoV-2 Spike (S) protein, which mediates the receptor recognition and membrane fusion between virus and host cells. Neutralizing antibodies (nAbs) targeting the S protein of SARS-CoV-2 have become promising candidates for clinical intervention strategy, while multiple studies have shown that different variants have enhanced infectivity and antibody resistance. Here, we explore the structure and function of STS165, a broadly inter-Spike bivalent nAb against SARS-CoV-2 variants and even SARS-CoV, contributing to further understanding of the working mechanism of nAbs. |
リンク | iScience / PubMed:35607524 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 3.3 - 3.8 Å |
構造データ | EMDB-33202, PDB-7xic: EMDB-33203, PDB-7xid: EMDB-33204: S-ECD (Omicron) in complex with PD of ACE2 focused on RBD_PD sub-complex |
化合物 | ChemComp-NAG: |
由来 |
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キーワード | VIRAL PROTEIN/IMMUNE SYSTEM (ウイルス性) / SARS-Cov-2 (SARSコロナウイルス2) / VIRAL PROTEIN (ウイルスタンパク質) / VIRAL PROTEIN-IMMUNE SYSTEM complex (ウイルス性) / VIRAL PROTEIN/HYDROLASE (ウイルス性) / VIRAL PROTEIN-HYDROLASE complex (ウイルス性) |