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TitleStructure and assembly of the NOT10:11 module of the CCR4-NOT complex.
Journal, issue, pagesCommun Biol, Vol. 6, Issue 1, Page 739, Year 2023
Publish dateJul 17, 2023
AuthorsYevgen Levdansky / Tobias Raisch / Justin C Deme / Filip Pekovic / Hans Elmlund / Susan M Lea / Eugene Valkov /
PubMed AbstractNOT1, NOT10, and NOT11 form a conserved module in the CCR4-NOT complex, critical for post-transcriptional regulation in eukaryotes, but how this module contributes to the functions of the CCR4-NOT ...NOT1, NOT10, and NOT11 form a conserved module in the CCR4-NOT complex, critical for post-transcriptional regulation in eukaryotes, but how this module contributes to the functions of the CCR4-NOT remains poorly understood. Here, we present cryo-EM structures of human and chicken NOT1:NOT10:NOT11 ternary complexes to sub-3 Å resolution, revealing an evolutionarily conserved, flexible structure. Through biochemical dissection studies, which include the Drosophila orthologs, we show that the module assembly is hierarchical, with NOT11 binding to NOT10, which then organizes it for binding to NOT1. A short proline-rich motif in NOT11 stabilizes the entire module assembly.
External linksCommun Biol / PubMed:37460791 / PubMed Central
MethodsEM (single particle)
Resolution2.57 - 2.88 Å
Structure data

29551

8fy3

EMDB-29551, PDB-8fy3:
Structure of NOT1:NOT10:NOT11 module of the human CCR4-NOT complex
Method: EM (single particle) / Resolution: 2.88 Å

29552

8fy4

EMDB-29552, PDB-8fy4:
Structure of NOT1:NOT10:NOT11 module of the chicken CCR4-NOT complex
Method: EM (single particle) / Resolution: 2.57 Å

Source
  • homo sapiens (human)
  • gallus gallus (chicken)
KeywordsRNA BINDING PROTEIN / mRNA degradation / gene expression

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