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-Structure paper
Title | Multifunctional RNA nanoparticles. |
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Journal, issue, pages | Nano Lett, Vol. 14, Issue 10, Page 5662-5671, Year 2014 |
Publish date | Oct 8, 2014 |
Authors | Kirill A Afonin / Mathias Viard / Alexey Y Koyfman / Angelica N Martins / Wojciech K Kasprzak / Martin Panigaj / Ravi Desai / Arti Santhanam / Wade W Grabow / Luc Jaeger / Eliahu Heldman / Jakob Reiser / Wah Chiu / Eric O Freed / Bruce A Shapiro / |
PubMed Abstract | Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully revealed. As presented here, ...Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully revealed. As presented here, besides functionalization with multiple different short interfering RNAs for combinatorial RNA interference (e.g., against multiple HIV-1 genes), nanorings also allow simultaneous embedment of assorted RNA aptamers, fluorescent dyes, proteins, as well as recently developed RNA-DNA hybrids aimed to conditionally activate multiple split functionalities inside cells. |
External links | Nano Lett / PubMed:25267559 / PubMed Central |
Methods | EM (single particle) |
Resolution | 16.0 Å |
Structure data | EMDB-2783: |
Source |
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