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TitleMultifunctional RNA nanoparticles.
Journal, issue, pagesNano Lett, Vol. 14, Issue 10, Page 5662-5671, Year 2014
Publish dateOct 8, 2014
AuthorsKirill A Afonin / Mathias Viard / Alexey Y Koyfman / Angelica N Martins / Wojciech K Kasprzak / Martin Panigaj / Ravi Desai / Arti Santhanam / Wade W Grabow / Luc Jaeger / Eliahu Heldman / Jakob Reiser / Wah Chiu / Eric O Freed / Bruce A Shapiro /
PubMed AbstractOur recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully revealed. As presented here, ...Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully revealed. As presented here, besides functionalization with multiple different short interfering RNAs for combinatorial RNA interference (e.g., against multiple HIV-1 genes), nanorings also allow simultaneous embedment of assorted RNA aptamers, fluorescent dyes, proteins, as well as recently developed RNA-DNA hybrids aimed to conditionally activate multiple split functionalities inside cells.
External linksNano Lett / PubMed:25267559 / PubMed Central
MethodsEM (single particle)
Resolution16.0 Å
Structure data

EMDB-2783:
siRNA Nanoring
Method: EM (single particle) / Resolution: 16.0 Å

Source
  • synthetic construct (others)

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