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-Structure paper
タイトル | Multifunctional RNA nanoparticles. |
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ジャーナル・号・ページ | Nano Lett, Vol. 14, Issue 10, Page 5662-5671, Year 2014 |
掲載日 | 2014年10月8日 |
![]() | Kirill A Afonin / Mathias Viard / Alexey Y Koyfman / Angelica N Martins / Wojciech K Kasprzak / Martin Panigaj / Ravi Desai / Arti Santhanam / Wade W Grabow / Luc Jaeger / Eliahu Heldman / Jakob Reiser / Wah Chiu / Eric O Freed / Bruce A Shapiro / ![]() |
PubMed 要旨 | Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully revealed. As presented here, ...Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully revealed. As presented here, besides functionalization with multiple different short interfering RNAs for combinatorial RNA interference (e.g., against multiple HIV-1 genes), nanorings also allow simultaneous embedment of assorted RNA aptamers, fluorescent dyes, proteins, as well as recently developed RNA-DNA hybrids aimed to conditionally activate multiple split functionalities inside cells. |
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手法 | EM (単粒子) |
解像度 | 16.0 Å |
構造データ | ![]() EMDB-2783: |
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