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TitleMolecular architecture of 40S initiation complexes on the Hepatitis C virus IRES: from ribosomal attachment to eIF5B-mediated reorientation of initiator tRNA
Journal, issue, pagesTo Be Published
Publish dateNov 25, 2021 (structure data deposition date)
AuthorsBrown ZP / Abaeva IS / De S / Hellen CUT / Pestova TV / Frank J
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.7 - 4.6 Å
Structure data

25527

7syg

EMDB-25527, PDB-7syg:
Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 1(delta dII)
Method: EM (single particle) / Resolution: 4.3 Å

25528

7syh

EMDB-25528, PDB-7syh:
Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 2(delta dII)
Method: EM (single particle) / Resolution: 4.6 Å

25534

7syn

EMDB-25534, PDB-7syn:
Structure of the HCV IRES bound to the 40S ribosomal subunit, head opening. Structure 8(delta dII)
Method: EM (single particle) / Resolution: 4.0 Å

EMDB-25600: Map of the wt IRES eIF5B-containing 48S initiation complex, closed conformation. eIF5B in position 1
Method: EM (single particle) / Resolution: 3.7 Å

EMDB-25601: Map of the wt IRES eIF5B-containing 48S initiation complex, closed conformation. eIF5B in position 2
Method: EM (single particle) / Resolution: 3.8 Å

Chemicals

ChemComp-ZN:
Unknown entry

Source
  • oryctolagus cuniculus (rabbit)
  • hepatitis c virus (isolate 1)
KeywordsRIBOSOME / HCV / IRES / 40S

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