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Structure paper

TitleMembrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant.
Journal, issue, pagesScience, Vol. 374, Issue 6573, Page 1353-1360, Year 2021
Publish dateDec 10, 2021
AuthorsJun Zhang / Tianshu Xiao / Yongfei Cai / Christy L Lavine / Hanqin Peng / Haisun Zhu / Krishna Anand / Pei Tong / Avneesh Gautam / Megan L Mayer / Richard M Walsh / Sophia Rits-Volloch / Duane R Wesemann / Wei Yang / Michael S Seaman / Jianming Lu / Bing Chen /
PubMed AbstractThe Delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has outcompeted previously prevalent variants and become a dominant strain worldwide. We report the structure, ...The Delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has outcompeted previously prevalent variants and become a dominant strain worldwide. We report the structure, function, and antigenicity of its full-length spike (S) trimer as well as those of the Gamma and Kappa variants, and compare their characteristics with the G614, Alpha, and Beta variants. Delta S can fuse membranes more efficiently at low levels of cellular receptor angiotensin converting enzyme 2 (ACE2), and its pseudotyped viruses infect target cells substantially faster than the other five variants, possibly accounting for its heightened transmissibility. Each variant shows different rearrangement of the antigenic surface of the amino-terminal domain of the S protein but only makes produces changes in the receptor binding domain (RBD), making the RBD a better target for therapeutic antibodies.
External linksScience / PubMed:34698504 / PubMed Central
MethodsEM (single particle)
Resolution3.1 - 4.4 Å
Structure data

24981

7sbk

EMDB-24981, PDB-7sbk:
Closed state of pre-fusion SARS-CoV-2 Delta variant spike protein
Method: EM (single particle) / Resolution: 3.1 Å

24982

7sbl

EMDB-24982, PDB-7sbl:
One RBD-up 1 of pre-fusion SARS-CoV-2 Delta variant spike protein
Method: EM (single particle) / Resolution: 3.4 Å

24983

7sbo

EMDB-24983, PDB-7sbo:
One RBD-up 2 of pre-fusion SARS-CoV-2 Delta variant spike protein
Method: EM (single particle) / Resolution: 4.3 Å

24984

7sbp

EMDB-24984, PDB-7sbp:
Closed state of pre-fusion SARS-CoV-2 Kappa variant spike protein
Method: EM (single particle) / Resolution: 3.1 Å

24985

7sbq

EMDB-24985, PDB-7sbq:
One RBD-up 1 of pre-fusion SARS-CoV-2 Kappa variant spike protein
Method: EM (single particle) / Resolution: 3.7 Å

24986

7sbr

EMDB-24986, PDB-7sbr:
One RBD-up 2 of pre-fusion SARS-CoV-2 Kappa variant spike protein
Method: EM (single particle) / Resolution: 4.3 Å

24987

7sbs

EMDB-24987, PDB-7sbs:
One RBD-up 1 of pre-fusion SARS-CoV-2 Gamma variant spike protein
Method: EM (single particle) / Resolution: 3.8 Å

24988

7sbt

EMDB-24988, PDB-7sbt:
One RBD-up 2 of pre-fusion SARS-CoV-2 Gamma variant spike protein
Method: EM (single particle) / Resolution: 4.4 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • severe acute respiratory syndrome coronavirus 2
KeywordsVIRAL PROTEIN

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