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-Structure paper
タイトル | Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant. |
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ジャーナル・号・ページ | Science, Vol. 374, Issue 6573, Page 1353-1360, Year 2021 |
掲載日 | 2021年12月10日 |
著者 | Jun Zhang / Tianshu Xiao / Yongfei Cai / Christy L Lavine / Hanqin Peng / Haisun Zhu / Krishna Anand / Pei Tong / Avneesh Gautam / Megan L Mayer / Richard M Walsh / Sophia Rits-Volloch / Duane R Wesemann / Wei Yang / Michael S Seaman / Jianming Lu / Bing Chen / |
PubMed 要旨 | The Delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has outcompeted previously prevalent variants and become a dominant strain worldwide. We report the structure, ...The Delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has outcompeted previously prevalent variants and become a dominant strain worldwide. We report the structure, function, and antigenicity of its full-length spike (S) trimer as well as those of the Gamma and Kappa variants, and compare their characteristics with the G614, Alpha, and Beta variants. Delta S can fuse membranes more efficiently at low levels of cellular receptor angiotensin converting enzyme 2 (ACE2), and its pseudotyped viruses infect target cells substantially faster than the other five variants, possibly accounting for its heightened transmissibility. Each variant shows different rearrangement of the antigenic surface of the amino-terminal domain of the S protein but only makes produces changes in the receptor binding domain (RBD), making the RBD a better target for therapeutic antibodies. |
リンク | Science / PubMed:34698504 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 3.1 - 4.4 Å |
構造データ | EMDB-24981, PDB-7sbk: EMDB-24982, PDB-7sbl: EMDB-24983, PDB-7sbo: EMDB-24984, PDB-7sbp: EMDB-24985, PDB-7sbq: EMDB-24986, PDB-7sbr: EMDB-24987, PDB-7sbs: EMDB-24988, PDB-7sbt: |
化合物 | ChemComp-NAG: |
由来 |
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キーワード | VIRAL PROTEIN |