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-Structure paper
Title | Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates. |
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Journal, issue, pages | PLoS Pathog, Vol. 16, Issue 8, Page e1008753, Year 2020 |
Publish date | Aug 31, 2020 |
![]() | Christopher A Cottrell / Jelle van Schooten / Charles A Bowman / Meng Yuan / David Oyen / Mia Shin / Robert Morpurgo / Patricia van der Woude / Mariëlle van Breemen / Jonathan L Torres / Raj Patel / Justin Gross / Leigh M Sewall / Jeffrey Copps / Gabriel Ozorowski / Bartek Nogal / Devin Sok / Eva G Rakasz / Celia Labranche / Vladimir Vigdorovich / Scott Christley / Diane G Carnathan / D Noah Sather / David Montefiori / Guido Silvestri / Dennis R Burton / John P Moore / Ian A Wilson / Rogier W Sanders / Andrew B Ward / Marit J van Gils / ![]() ![]() |
PubMed Abstract | The induction of broad and potent immunity by vaccines is the key focus of research efforts aimed at protecting against HIV-1 infection. Soluble native-like HIV-1 envelope glycoproteins have shown ...The induction of broad and potent immunity by vaccines is the key focus of research efforts aimed at protecting against HIV-1 infection. Soluble native-like HIV-1 envelope glycoproteins have shown promise as vaccine candidates as they can induce potent autologous neutralizing responses in rabbits and non-human primates. In this study, monoclonal antibodies were isolated and characterized from rhesus macaques immunized with the BG505 SOSIP.664 trimer to better understand vaccine-induced antibody responses. Our studies reveal a diverse landscape of antibodies recognizing immunodominant strain-specific epitopes and non-neutralizing neo-epitopes. Additionally, we isolated a subset of mAbs against an epitope cluster at the gp120-gp41 interface that recognize the highly conserved fusion peptide and the glycan at position 88 and have characteristics akin to several human-derived broadly neutralizing antibodies. |
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Methods | EM (single particle) / X-ray diffraction |
Resolution | 1.85 - 29.0 Å |
Structure data | ![]() EMDB-21053: ![]() EMDB-21055: ![]() EMDB-21056: ![]() EMDB-21057: ![]() EMDB-21058: ![]() EMDB-21059: ![]() EMDB-21061: ![]() EMDB-21062: ![]() EMDB-21064: ![]() EMDB-21065: ![]() EMDB-21066: ![]() EMDB-21075: ![]() EMDB-21076: ![]() EMDB-21077: ![]() EMDB-21078: ![]() EMDB-21079: ![]() EMDB-21080: ![]() EMDB-21081: ![]() EMDB-21082: ![]() EMDB-21083: ![]() EMDB-21084: ![]() EMDB-21085: ![]() EMDB-21086: ![]() EMDB-21087: ![]() EMDB-21088: ![]() EMDB-21089: ![]() EMDB-21090: ![]() EMDB-21091: ![]() EMDB-21092: ![]() EMDB-21093: EMDB-21232, PDB-6vlr: EMDB-21246, PDB-6vn0: EMDB-21257, PDB-6vo1: ![]() EMDB-21272: ![]() EMDB-21273: ![]() EMDB-21274: ![]() EMDB-21275: ![]() EMDB-21276: ![]() EMDB-21277: ![]() EMDB-21278: ![]() PDB-6vor: ![]() PDB-6vos: ![]() PDB-6vsr: |
Chemicals | ![]() ChemComp-NAG: ![]() ChemComp-GLY: ![]() ChemComp-HOH: ![]() ChemComp-TAM: ![]() ChemComp-2PE: ![]() ChemComp-P6G: ![]() ChemComp-PE8: ![]() ChemComp-SO4: |
Source |
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![]() | VIRAL PROTEIN/IMMUNE SYSTEM / HIV / antibody / Fab / vaccine / VIRAL PROTEIN / VIRAL PROTEIN-IMMUNE SYSTEM complex / Rhesus macaque / IMMUNE SYSTEM / non-human primates |