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TitleStructure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP.
Journal, issue, pagesNat Commun, Vol. 15, Issue 1, Page 2476, Year 2024
Publish dateMar 20, 2024
AuthorsHongtao Liu / Dariusz Zakrzewicz / Kamil Nosol / Rossitza N Irobalieva / Somnath Mukherjee / Rose Bang-Sørensen / Nora Goldmann / Sebastian Kunz / Lorenzo Rossi / Anthony A Kossiakoff / Stephan Urban / Dieter Glebe / Joachim Geyer / Kaspar P Locher /
PubMed AbstractCellular entry of the hepatitis B and D viruses (HBV/HDV) requires binding of the viral surface polypeptide preS1 to the hepatobiliary transporter Na-taurocholate co-transporting polypeptide (NTCP). ...Cellular entry of the hepatitis B and D viruses (HBV/HDV) requires binding of the viral surface polypeptide preS1 to the hepatobiliary transporter Na-taurocholate co-transporting polypeptide (NTCP). This interaction can be blocked by bulevirtide (BLV, formerly Myrcludex B), a preS1 derivative and approved drug for treating HDV infection. Here, to elucidate the basis of this inhibitory function, we determined a cryo-EM structure of BLV-bound human NTCP. BLV forms two domains, a plug lodged in the bile salt transport tunnel of NTCP and a string that covers the receptor's extracellular surface. The N-terminally attached myristoyl group of BLV interacts with the lipid-exposed surface of NTCP. Our structure reveals how BLV inhibits bile salt transport, rationalizes NTCP mutations that decrease the risk of HBV/HDV infection, and provides a basis for understanding the host specificity of HBV/HDV. Our results provide opportunities for structure-guided development of inhibitors that target HBV/HDV docking to NTCP.
External linksNat Commun / PubMed:38509088 / PubMed Central
MethodsEM (single particle)
Resolution3.41 Å
Structure data

19440

8rqf

EMDB-19440, PDB-8rqf:
Cryo-EM structure of human NTCP-Bulevirtide complex
Method: EM (single particle) / Resolution: 3.41 Å

Chemicals


ChemComp, No image

ChemComp-BJU:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • lama glama (llama)
  • hepatitis b virus genotype c
KeywordsTRANSPORT PROTEIN / Hepatitis B/D virus receptor / bile salt transporter / drugs / inhibitor

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