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-Structure paper
Title | Complex of human APH-1B isoform of gamma-secretase with Amyloid-beta in lipid environment suggests substrate shifting as the mechanism of sequential cleavage |
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Journal, issue, pages | To Be Published |
Publish date | Apr 12, 2023 (structure data deposition date) |
Authors | Odorcic I |
External links | Search PubMed |
Methods | EM (single particle) |
Resolution | 3.3 - 3.4 Å |
Structure data | EMDB-17112, PDB-8oqy: EMDB-17113, PDB-8oqz: |
Chemicals | ChemComp-NAG: ChemComp-PC1: |
Source |
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Keywords | MEMBRANE PROTEIN / intramembrane proteolysis / protease / di-aspartyl protease / Alzheimer's disease / complex / amyloid beta |