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Structure paper

TitleDrug-induced rotational movement of the ribosome is a key factor for read-through enhancement
Journal, issue, pagesTo Be Published
Publish dateMar 20, 2023 (structure data deposition date)
AuthorsKolosova, O. / Zgadzay, Y. / Stetsenko, A. / Validov, S. / Usachev, K. / Jenner, L. / Dmitriev, S. / Guskov, A. / Yusupov, M.
External linksSearch PubMed
MethodsEM (single particle) / X-ray diffraction
Resolution2.9 - 3.5 Å
Structure data

16874

8ogj

EMDB-16874, PDB-8ogj:
Structure of Candida albicans 80S ribosome in complex with mefloquine
Method: EM (single particle) / Resolution: 3.1 Å

EMDB-16920: 40S body focused map of Candida albicans 80S ribosome in complex with mefloquine
Method: EM (single particle) / Resolution: 3.1 Å

EMDB-16921: 40S head focused map of Candida albicans 80S ribosome in complex with mefloquine
Method: EM (single particle) / Resolution: 3.1 Å

EMDB-16922: Combined map of Candida albicans 80S ribosome in complex with mefloquine
Method: EM (single particle) / Resolution: 3.1 Å

PDB-8cq7:
Crystal structure of phyllanthoside bound to the Candida albicans 80S ribosome
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

PDB-8cqw:
Crystal structure of the Candida albicans 80S ribosome in complex with Hygromycin B
Method: X-RAY DIFFRACTION / Resolution: 3.05 Å

PDB-8cre:
Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-8oeq:
Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (250uM)
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

PDB-8oh6:
Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (500umol)
Method: X-RAY DIFFRACTION / Resolution: 3.35 Å

PDB-8oi5:
Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (2mM)
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-8oj3:
Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418 (rotated state)
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

Chemicals

ChemComp-3K5:
3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2'S,3a'R,4''S,5''R,6'S,7a'S)-5''-methyl-4''-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3'-[1]benzofuran-2',2''-pyran]-6'-yl]carbonyl}-beta-D-glucopyranose

ChemComp-MG:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-HYG:
HYGROMYCIN B / antibiotic*YM

ChemComp-GET:
GENETICIN / antibiotic*YM

ChemComp-PAR:
PAROMOMYCIN / Antimicrobial, medication*YM

ChemComp-YMZ:
Mefloquine / medication*YM

ChemComp-SPK:
SPERMINE (FULLY PROTONATED FORM)

Source
  • candida albicans (yeast)
  • candida (fungus)
KeywordsRIBOSOME / Candida albicans / phyllanthoside / hygromycin B / geneticin / G418 / paromomycin / mefloquine / PTC read-through

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