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TitleStructure of a cholinergic cell membrane.
Journal, issue, pagesProc Natl Acad Sci U S A, Vol. 119, Issue 34, Page e2207641119, Year 2022
Publish dateAug 23, 2022
AuthorsNigel Unwin /
PubMed AbstractCell membranes are complex assemblies of proteins and lipids making transient or long-term associations that have yet to be characterized at a molecular level. Here, cryo-electron microscopy is ...Cell membranes are complex assemblies of proteins and lipids making transient or long-term associations that have yet to be characterized at a molecular level. Here, cryo-electron microscopy is applied to determine how phospholipids and cholesterol arrange between neighboring proteins (nicotinic acetylcholine receptors) of cholinergic membrane. The lipids exhibit distinct properties in the two leaflets of the bilayer, influenced by the protein surfaces and by differences in cholesterol concentration. In the outer leaflet, the lipids show no consistent motif away from the protein surfaces, in keeping with their assumed fluidity. In the inner leaflet, where the cholesterol concentration is higher, the lipids organize into extensive close-packed linear arrays. These arrays are built from the sterol groups of cholesterol and the initial saturated portions of the phospholipid hydrocarbon chains. Together, they create an ordered ∼7 Å-thick "skin" within the hydrophobic core of the bilayer. The packing of lipids in the arrays appears to bear a close relationship to the linear cholesterol arrays that form crystalline monolayers at the air-water interface.
External linksProc Natl Acad Sci U S A / PubMed:35969788 / PubMed Central
MethodsEM (helical sym.)
Resolution5.5 Å
Structure data

EMDB-14942: Map1 from paper entitled: Structure of a cholinergic cell membrane
Method: EM (helical sym.) / Resolution: 5.5 Å

EMDB-14946: Map2 from paper entitled: Structure of a cholinergic cell membrane
Method: EM (helical sym.) / Resolution: 5.5 Å

Source
  • Torpedo marmorata (marbled electric ray)

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