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TitleAdaptation to genome decay in the structure of the smallest eukaryotic ribosome.
Journal, issue, pagesNat Commun, Vol. 13, Issue 1, Page 591, Year 2022
Publish dateFeb 1, 2022
AuthorsDavid Nicholson / Marco Salamina / Johan Panek / Karla Helena-Bueno / Charlotte R Brown / Robert P Hirt / Neil A Ranson / Sergey V Melnikov /
PubMed AbstractThe evolution of microbial parasites involves the counterplay between natural selection forcing parasites to improve and genetic drifts forcing parasites to lose genes and accumulate deleterious ...The evolution of microbial parasites involves the counterplay between natural selection forcing parasites to improve and genetic drifts forcing parasites to lose genes and accumulate deleterious mutations. Here, to understand how this counterplay occurs at the scale of individual macromolecules, we describe cryo-EM structure of ribosomes from Encephalitozoon cuniculi, a eukaryote with one of the smallest genomes in nature. The extreme rRNA reduction in E. cuniculi ribosomes is accompanied with unparalleled structural changes, such as the evolution of previously unknown molten rRNA linkers and bulgeless rRNA. Furthermore, E. cuniculi ribosomes withstand the loss of rRNA and protein segments by evolving an ability to use small molecules as structural mimics of degenerated rRNA and protein segments. Overall, we show that the molecular structures long viewed as reduced, degenerated, and suffering from debilitating mutations possess an array of compensatory mechanisms that allow them to remain active despite the extreme molecular reduction.
External linksNat Commun / PubMed:35105900 / PubMed Central
MethodsEM (single particle)
Resolution2.7 Å
Structure data

13936

7qep

EMDB-13936, PDB-7qep:
Cryo-EM structure of the ribosome from Encephalitozoon cuniculi
Method: EM (single particle) / Resolution: 2.7 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM

ChemComp-SPD:
SPERMIDINE

Source
  • Encephalitozoon cuniculi (fungus)
  • encephalitozoon cuniculi gb-m1 (fungus)
KeywordsRIBOSOME / genome decay / microbial parasite / genome reduction / Encephalitozoon cuniculi / lose-to-gain

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