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TitleA small ribosome-associated ncRNA globally inhibits translation by restricting ribosome dynamics.
Journal, issue, pagesRNA Biol, Vol. 18, Issue 12, Page 2617-2632, Year 2021
Publish dateJun 13, 2021
AuthorsJulia Reuther / Lukas Schneider / Ioan Iacovache / Andreas Pircher / Walid H Gharib / Benoît Zuber / Norbert Polacek /
PubMed AbstractRibosome-associated non-coding RNAs (rancRNAs) have been recognized as an emerging class of regulatory molecules capable of fine-tuning translation in all domains of life. RancRNAs are ideally suited ...Ribosome-associated non-coding RNAs (rancRNAs) have been recognized as an emerging class of regulatory molecules capable of fine-tuning translation in all domains of life. RancRNAs are ideally suited for allowing a swift response to changing environments and are therefore considered pivotal during the first wave of stress adaptation. Previously, we identified an mRNA-derived 18 nucleotides long rancRNA (rancRNA_18) in that rapidly downregulates protein synthesis during hyperosmotic stress. However, the molecular mechanism of action remained enigmatic. Here, we combine biochemical, genetic, transcriptome-wide and structural evidence, thus revealing rancRNA_18 as global translation inhibitor by targeting the E-site region of the large ribosomal subunit. Ribosomes carrying rancRNA_18 possess decreased affinity for A-site tRNA and impaired structural dynamics. Cumulatively, these discoveries reveal the mode of action of a rancRNA involved in modulating protein biosynthesis at a thus far unequalled precision.
External linksRNA Biol / PubMed:34121604 / PubMed Central
MethodsEM (single particle)
Resolution4.4 - 5.1 Å
Structure data

EMDB-12986:
Control sample rancRNA_18
Method: EM (single particle) / Resolution: 5.1 Å

EMDB-12988:
rancRNA_18 processing and classification
Method: EM (single particle) / Resolution: 4.4 Å

Source
  • Saccharomyces cerevisiae (brewer's yeast)

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