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Title | The dynamics of signal triggering in a gp130-receptor complex. |
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Journal, issue, pages | Structure, Vol. 15, Issue 4, Page 441-448, Year 2007 |
Publish date | Oct 3, 2007 |
Authors | Rishi Matadeen / Wai-Ching Hon / John K Heath / E Yvonne Jones / Stephen Fuller / |
PubMed Abstract | gp130 is a shared signal-transducing membrane-associated receptor for several hematopoietic cytokines. The 30 A resolution cryo-electron microscopy (cryo-EM) structure of the Interleukin 11(IL-11)-IL- ...gp130 is a shared signal-transducing membrane-associated receptor for several hematopoietic cytokines. The 30 A resolution cryo-electron microscopy (cryo-EM) structure of the Interleukin 11(IL-11)-IL-11 Receptor-gp130 extracellular complex reveals the architecture and dynamics of this gp130-containing signaling complex. Normal-mode analysis reveals a repertoire of conformational changes that could function in signal triggering. This suggests a concerted mechanism of signaling involving all the components of the complex. This could provide a general mechanism of signal transfer for cytokines utilizing the JAK-STAT signaling cascade. |
External links | Structure / PubMed:17437716 / PubMed Central |
Methods | EM (single particle) |
Resolution | 30.0 Å |
Structure data | EMDB-1223: |
Source |
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