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TitleDynamics in the murine norovirus capsid revealed by high-resolution cryo-EM.
Journal, issue, pagesPLoS Biol, Vol. 18, Issue 3, Page e3000649, Year 2020
Publish dateMar 31, 2020
AuthorsJoseph S Snowden / Daniel L Hurdiss / Oluwapelumi O Adeyemi / Neil A Ranson / Morgan R Herod / Nicola J Stonehouse /
PubMed AbstractIcosahedral viral capsids must undergo conformational rearrangements to coordinate essential processes during the viral life cycle. Capturing such conformational flexibility has been technically ...Icosahedral viral capsids must undergo conformational rearrangements to coordinate essential processes during the viral life cycle. Capturing such conformational flexibility has been technically challenging yet could be key for developing rational therapeutic agents to combat infections. Noroviruses are nonenveloped, icosahedral viruses of global importance to human health. They are a common cause of acute gastroenteritis, yet no vaccines or specific antiviral agents are available. Here, we use genetics and cryo-electron microscopy (cryo-EM) to study the high-resolution solution structures of murine norovirus as a model for human viruses. By comparing our 3 structures (at 2.9- to 3.1-Å resolution), we show that whilst there is little change to the shell domain of the capsid, the radiating protruding domains are flexible, adopting distinct states both independently and synchronously. In doing so, the capsids sample a range of conformational space, with implications for maintaining virion stability and infectivity.
External linksPLoS Biol / PubMed:32231352 / PubMed Central
MethodsEM (single particle)
Resolution2.9 - 3.1 Å
Structure data

10103

6s6l

EMDB-10103, PDB-6s6l:
Cryo-EM structure of murine norovirus (MNV-1)
Method: EM (single particle) / Resolution: 3.1 Å

EMDB-10127:
Thermally-inactivated murine norovirus (MNV-1)
Method: EM (single particle) / Resolution: 2.9 Å

EMDB-10128:
Thermally-stabilised mutant murine norovirus (MNV-1)
Method: EM (single particle) / Resolution: 3.1 Å

Source
  • murine norovirus 1
KeywordsVIRUS / Norovirus / Capsid / VP1

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