タイトル | Structure-based design of peptide epoxyketones selectively targeting the three human immunoproteasome active sites |
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ジャーナル・号・ページ | To Be Published |
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掲載日 | 2024年6月21日 (構造データの登録日) |
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著者 | Maurits, E. / Huber, E.M. / Dekker, P.M. / Wang, X. / Heinemeyer, W. / Florea, B.I. / Groll, M. / Overkleeft, H.S. |
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リンク | PubMedで検索 |
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手法 | X線回折 |
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解像度 | 2.6 - 2.75 Å |
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構造データ | PDB-9fst: Yeast 20S proteasome with human beta1i (1-51) in complex with epoxyketone inhibitor LU-001i 手法: X-RAY DIFFRACTION / 解像度: 2.75 Å PDB-9fsv: Yeast 20S proteasome with human beta2i (1-53) in complex with epoxyketone inhibitor 42 手法: X-RAY DIFFRACTION / 解像度: 2.75 Å PDB-9ft0: Yeast 20S proteasome in complex with epoxyketone inhibitor 42 手法: X-RAY DIFFRACTION / 解像度: 2.75 Å PDB-9ft1: Yeast 20S proteasome in complex with epoxyketone inhibitor 13 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å |
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化合物 | PDB-1if8: Carbonic Anhydrase II Complexed With (S)-N-(3-Indol-1-yl-2-methyl-propyl)-4-sulfamoyl-benzamide
PDB-1ifl: MOLECULAR MODELS AND STRUCTURAL COMPARISONS OF NATIVE AND MUTANT CLASS I FILAMENTOUS BACTERIOPHAGES FF (FD, F1, M13), IF1 AND IKE
PDB-1ifk: MOLECULAR MODELS AND STRUCTURAL COMPARISONS OF NATIVE AND MUTANT CLASS I FILAMENTOUS BACTERIOPHAGES FF (FD, F1, M13), IF1 AND IKE
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由来 | homo sapiens (ヒト)![](img/tx_yeast.gif) saccharomyces cerevisiae (パン酵母)- synthetic construct (人工物)
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キーワード | HYDROLASE / Proteasome / Mutant / Human Chimeric Subunit / Structure-based Drug Development / Inhibitor / Binding Analysis / Yeast 20S proteasome in complex with epoxyketone inhibitor 13 |
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