EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of beta-Glucocerebrosidase.
ジャーナル・号・ページ	J. Med. Chem., Vol. 67, Page 11168-11181, Year 2024
掲載日	2024年5月9日 (構造データの登録日)
著者	Palmer, N. / Agnew, C. / Benn, C. / Buffham, W.J. / Castro, J.N. / Chessari, G. / Clark, M. / Cons, B.D. / Coyle, J.E. / Dawson, L.A. ...Palmer, N. / Agnew, C. / Benn, C. / Buffham, W.J. / Castro, J.N. / Chessari, G. / Clark, M. / Cons, B.D. / Coyle, J.E. / Dawson, L.A. / Hamlett, C.C.F. / Hodson, C. / Holding, F. / Johnson, C.N. / Liebeschuetz, J.W. / Mahajan, P. / McCarthy, J.M. / Murray, C.W. / O'Reilly, M. / Peakman, T. / Price, A. / Rapti, M. / Reeks, J. / Schopf, P. / St-Denis, J.D. / Valenzano, C. / Wallis, N.G. / Walser, R. / Weir, H. / Wilsher, N.E. / Woodhead, A. / Bento, C.F. / Tisi, D.
リンク	J. Med. Chem. / PubMed:38932616
手法	X線回折
解像度	1.14 - 2.279 Å
構造データ	PDB-9f9z: Gcase in complex with small molecule inhibitor 1 手法: X-RAY DIFFRACTION / 解像度: 2.279 Å PDB-9fa3: Gcase in complex with small molecule inhibitor 1 手法: X-RAY DIFFRACTION / 解像度: 1.36 Å PDB-9fa6: Gcase in complex with small molecule inhibitor 1 手法: X-RAY DIFFRACTION / 解像度: 1.49 Å PDB-9fad: Gcase in complex with small molecule inhibitor 1 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-9fal: Gcase in complex with small molecule inhibitor 1 手法: X-RAY DIFFRACTION / 解像度: 1.39 Å PDB-9fay: Gcase in complex with small molecule inhibitor 1 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-9faz: Gcase in complex with small molecule inhibitor 1 手法: X-RAY DIFFRACTION / 解像度: 1.63 Å PDB-9fb2: Gcase in complex with small molecule inhibitor 1 手法: X-RAY DIFFRACTION / 解像度: 1.14 Å PDB-9fdi: Gcase in complex with small molecule inhibitor 1 手法: X-RAY DIFFRACTION / 解像度: 1.41 Å
化合物	ChemComp-K: Unknown entry / カリウムカチオン ChemComp-SO4: SULFATE ION / 硫酸ジアニオン PDB-1ibi: QUAIL CYSTEINE AND GLYCINE-RICH PROTEIN, NMR, 15 MINIMIZED MODEL STRUCTURES ChemComp-HOH: WATER ChemComp-NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose / N-アセチル-β-D-グルコサミン PDB-1ibc: CRYSTAL STRUCTURE OF INHIBITED INTERLEUKIN-1BETA CONVERTING ENZYME PDB-1ibe: DEOXY-HAEMOGLOBIN TRAPPED IN THE HIGH-AFFINITY (R) STATE PDB-1ibg: STRUCTURE AND SPECIFICITY OF THE ANTI-DIGOXIN ANTIBODY 40-50 PDB-1ibd: X-RAY 3D STRUCTURE OF P.LEIOGNATHI CU,ZN SOD MUTANT V29A ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル PDB-1ibq: ASPERGILLOPEPSIN FROM ASPERGILLUS PHOENICIS ChemComp-BAQ: pyrrolidin-2-one / ピロリドン ChemComp-PEG: DI(HYDROXYETHYL)ETHER / ジエチレングリコ-ル PDB-1ibr: COMPLEX OF RAN WITH IMPORTIN BETA ChemComp-DMS: DIMETHYL SULFOXIDE / 2-チアプロパン2-オキシド / DMSO, 沈殿剤YM PDB-1ibp: Unknown entry PDB-1ibo: NMR STRUCTURE OF HEMAGGLUTININ FUSION PEPTIDE IN DPC MICELLES AT PH 7.4 PDB-1ib1*: CRYSTAL STRUCTURE OF THE 14-3-3 ZETA:SEROTONIN N-ACETYLTRANSFERASE COMPLEX
由来	homo sapiens (ヒト)
キーワード	LIPID BINDING PROTEIN / Glycosidase / cholesterol metabolism / steroid metabolism / glycosyl transferase