Mechanism for drastic reduction in catalytic activity of Trp89Phe-mutated glutamate dehydrogenase revealed by crystal structure and cryoEM-sampling of metastable conformation in action
EMDB-60266, PDB-8znb: Cryo-EM structure of W89F mutated Glutamate dehydrogenase from Thermococcus profundus incorporating NADPH in the steady stage of reaction 手法: EM (単粒子) / 解像度: 2.53 Å
EMDB-60267, PDB-8znc: Cryo-EM structure of W89F mutated Glutamate dehydrogenase from Thermococcus profundus incorporating NADPH, AKG in the steady stage of reaction 手法: EM (単粒子) / 解像度: 2.41 Å
EMDB-60268, PDB-8znd: Cryo-EM structure of W89F mutated Glutamate dehydrogenase from Thermococcus profundus incorporating NADPH and a substrate in the steady stage of reaction 手法: EM (単粒子) / 解像度: 2.53 Å
EMDB-60270, PDB-8zng: Cryo-EM structure of W89F mutated Glutamate dehydrogenase from Thermococcus profundus in complex with NADPH and AKG in the steady stage of reaction 手法: EM (単粒子) / 解像度: 2.5 Å