タイトル | Structural basis for substrate and antibiotic recognition by Helicobacter pylori isoleucyl-tRNA synthetase. |
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ジャーナル・号・ページ | Febs Lett., Vol. 598, Page 521-536, Year 2024 |
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掲載日 | 2023年10月5日 (構造データの登録日) |
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著者 | Chen, X. / Guo, Y. / Shi, J. / Wang, Y. / Guo, X. / Wu, G. / Li, S. / Zhang, T. |
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リンク | Febs Lett. / PubMed:38246751 |
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手法 | X線回折 |
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解像度 | 1.78 - 2.34 Å |
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構造データ | PDB-8wnf: Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in apo form 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-8wng: Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in complex with Ile 手法: X-RAY DIFFRACTION / 解像度: 1.92 Å PDB-8wni: Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in complex with Val 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-8wnj: Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in complex with Ile-AMP 手法: X-RAY DIFFRACTION / 解像度: 1.78 Å PDB-8wo2: Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in complex with Val-AMP 手法: X-RAY DIFFRACTION / 解像度: 2.34 Å PDB-8wo3: Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in complex with Mupirocin 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å |
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化合物 | ChemComp-GV6: [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] (2S,3S)-2-azanyl-3-methyl-pentanoate / イソロイシルアデニル酸
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由来 | - helicobacter pylori (ピロリ菌)
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キーワード | LIGASE / isoleucyl-tRNA synthetase / Helicobacter pylori / HpIleRS / IleRS / aminoacylation |
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