タイトル | Protein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design. |
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ジャーナル・号・ページ | Structure, Vol. 32, Page 1040-1048.e3, Year 2024 |
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掲載日 | 2023年11月30日 (構造データの登録日) |
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著者 | Mukherjee, M. / Day, P.J. / Laverty, D. / Bueren-Calabuig, J.A. / Woodhead, A.J. / Griffiths-Jones, C. / Hiscock, S. / East, C. / Boyd, S. / O'Reilly, M. |
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リンク | Structure / PubMed:38870939 |
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手法 | X線回折 |
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解像度 | 1.51 - 2.78 Å |
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構造データ | PDB-8r99: A soakable crystal form of human CDK7 in complex with AMP-PNP 手法: X-RAY DIFFRACTION / 解像度: 1.81 Å PDB-8r9a: A soakable crystal form of human CDK7 in complex with AMP-PNP 手法: X-RAY DIFFRACTION / 解像度: 1.71 Å PDB-8r9b: A soakable crystal form of human CDK7 in complex with AMP-PNP 手法: X-RAY DIFFRACTION / 解像度: 2.21 Å PDB-8r9o: A soakable crystal form of human CDK7 in complex with AMP-PNP 手法: X-RAY DIFFRACTION / 解像度: 2.22 Å PDB-8r9s: A soakable crystal form of human CDK7 in complex with AMP-PNP 手法: X-RAY DIFFRACTION / 解像度: 2.78 Å PDB-8r9u: A soakable crystal form of human CDK7 in complex with AMP-PNP 手法: X-RAY DIFFRACTION / 解像度: 1.937 Å PDB-8ru8: A crystal form of a human CDK2-CDK7 chimera 手法: X-RAY DIFFRACTION / 解像度: 1.51 Å |
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化合物 | ChemComp-ANP: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP / AMP-PNP, エネルギー貯蔵分子類似体*YM
ChemComp-I74: (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol
ChemComp-PE3: 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL / 3,6,9,12,15,18,21,24,27,30,33,36,39-トリデカオキサヘンテトラコンタン-1,41-ジ(以下略)
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由来 | homo sapiens (ヒト)
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キーワード | CELL CYCLE / serine-threonine kinase / phosphorylation / cell cycle progression / ATP binding / SIGNALING PROTEIN / cyclin dependent kinase 7 / serine/threonine kinase / cell cycle kinase |
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