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-Structure paper
タイトル | A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity. |
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ジャーナル・号・ページ | Cell Rep Med, Vol. 5, Issue 5, Page 101553, Year 2024 |
掲載日 | 2024年5月21日 |
著者 | Chang Liu / Daming Zhou / Aiste Dijokaite-Guraliuc / Piyada Supasa / Helen M E Duyvesteyn / Helen M Ginn / Muneeswaran Selvaraj / Alexander J Mentzer / Raksha Das / Thushan I de Silva / Thomas G Ritter / Megan Plowright / Thomas A H Newman / Lizzie Stafford / Barbara Kronsteiner / Nigel Temperton / Yuan Lui / Martin Fellermeyer / Philip Goulder / Paul Klenerman / Susanna J Dunachie / Michael I Barton / Mikhail A Kutuzov / Omer Dushek / / Elizabeth E Fry / Juthathip Mongkolsapaya / Jingshan Ren / David I Stuart / Gavin R Screaton / |
PubMed 要旨 | BA.2.86, a recently described sublineage of SARS-CoV-2 Omicron, contains many mutations in the spike gene. It appears to have originated from BA.2 and is distinct from the XBB variants responsible ...BA.2.86, a recently described sublineage of SARS-CoV-2 Omicron, contains many mutations in the spike gene. It appears to have originated from BA.2 and is distinct from the XBB variants responsible for many infections in 2023. The global spread and plethora of mutations in BA.2.86 has caused concern that it may possess greater immune-evasive potential, leading to a new wave of infection. Here, we examine the ability of BA.2.86 to evade the antibody response to infection using a panel of vaccinated or naturally infected sera and find that it shows marginally less immune evasion than XBB.1.5. We locate BA.2.86 in the antigenic landscape of recent variants and look at its ability to escape panels of potent monoclonal antibodies generated against contemporary SARS-CoV-2 infections. We demonstrate, and provide a structural explanation for, increased affinity of BA.2.86 to ACE2, which may increase transmissibility. |
リンク | Cell Rep Med / PubMed:38723626 / PubMed Central |
手法 | EM (単粒子) / X線回折 |
解像度 | 2.3 - 4.03 Å |
構造データ | EMDB-18639, PDB-8qsq: EMDB-18649, PDB-8qtd: EMDB-19002, PDB-8r8k: PDB-8qrf: PDB-8qrg: PDB-8r80: |
化合物 | ChemComp-NAG: ChemComp-GOL: ChemComp-HOH: |
由来 |
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キーワード | VIRAL PROTEIN / Viral protein/immune system / SARS-CoV-2 / RBD / XBB-6 / Beta-49 / BA.2.86 / XBB.1.5 / immune system / ACE2 / Spike / glycoprotein / angiotensin converting enzyme 2 / receptor / coronavirus-2 / XBB-7 / XBB.1.5.10 / XBB.1.5.70 / Coronavirus / antibody / Fab / therapeutic / complex / neutralising / receptor binding domain / convalescent sera / XBB-4 / BA.2.12.1 / omicron variant / virus |