EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field.
ジャーナル・号・ページ	Acs Med. Chem. Lett., Vol. 14, Page 949-954, Year 2023
掲載日	2023年3月19日 (構造データの登録日)
著者	Vulpetti, A. / Holzer, P. / Schmiedeberg, N. / Imbach-Weese, P. / Pissot-Soldermann, C. / Hollingworth, G.J. / Radimerski, T. / Thoma, C.R. / Stachyra, T.M. / Wojtynek, M. ...Vulpetti, A. / Holzer, P. / Schmiedeberg, N. / Imbach-Weese, P. / Pissot-Soldermann, C. / Hollingworth, G.J. / Radimerski, T. / Thoma, C.R. / Stachyra, T.M. / Wojtynek, M. / Maschlej, M. / Chau, S. / Schuffenhauer, A. / Fernandez, C. / Schroder, M. / Renatus, M.
リンク	Acs Med. Chem. Lett. / PubMed:37465299
手法	X線回折
解像度	2.09 - 2.945 Å
構造データ	PDB-8og5: Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 1 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-8og6: Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 1 手法: X-RAY DIFFRACTION / 解像度: 2.245 Å PDB-8og7: Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 2 手法: X-RAY DIFFRACTION / 解像度: 2.64 Å PDB-8og8: Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 3 手法: X-RAY DIFFRACTION / 解像度: 2.11 Å PDB-8og9: Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 4 手法: X-RAY DIFFRACTION / 解像度: 2.945 Å PDB-8oga: Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 6 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-8ogb: Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 8 手法: X-RAY DIFFRACTION / 解像度: 2.27 Å PDB-8ogc: Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 11 手法: X-RAY DIFFRACTION / 解像度: 2.09 Å
化合物	ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-ACT: ACETATE ION / 酢酸イオン ChemComp-LQH: 5-(2-fluorophenyl)-2,3-dihydroimidazo[2,1-a]isoquinoline ChemComp-HOH: WATER ChemComp-VMR: (4~{R})-4-[3-(4-chloranylphenoxy)phenyl]pyrrolidin-2-imine ChemComp-VM8: 5-(2-methyl-1-phenyl-propan-2-yl)imidazo[2,1-a]isoquinoline ChemComp-VM3: 5-[1-(4-chlorophenyl)cyclopropyl]imidazo[2,1-a]isoquinoline ChemComp-DMS: DIMETHYL SULFOXIDE / 2-チアプロパン2-オキシド / DMSO, 沈殿剤YM ChemComp-VLW: 5-[1-(4-methoxyphenyl)cyclopropyl]-8-(4-methylpiperazin-1-yl)-2,3-dihydroimidazo[2,1-a]isoquinoline ChemComp-VN5: ~{N}'-[2-[1-(4-methoxyphenyl)cyclopropyl]-7-(4-methylpiperazin-1-yl)quinazolin-4-yl]ethane-1,2-diamine ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-VMZ*: 1-[4-[4-(2-azanylethylamino)-2-[1-(4-chlorophenyl)cyclopentyl]quinazolin-7-yl]piperazin-1-yl]ethanone
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE / DCAF1 / E3 ligase / compound